""My concern is that I need Jak 1 and 3 blocked, but there is no medicationt that does that concentrated, right? Litfulo was supposed to be, but they stopped it do to safety concerns it seems like. "
JAK3 is blocking same cytokines (ILs)…"
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Upadacitinib provides great results refractory to other JAKs.
Started Feb 16 0 Replies 0 Likes
Hi.Im aleopacia patient that participated in ritlecitinib, deuruxolitinib and upadacitinib studies. Upadacitinib gives effects in cases refractory to other medicines also inclusion of…Continue
Tags: ritlecitinib, aleopacia, universalis, deuruxolitinib, ruxolitinib
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"@nhazir
I dont know your disease history. Do you have any break of treatment and when did that occur? What JAK you tried before Litfulo. If you are currently sheeding on Litfulo 50mg and you didnt have any break of treatment then I would switch to…"
"I can also look to switch to Baricitnib/Leqselvi, but worried it also doesnt work. Also worried about the time from when I am off of Litfulo and just starting the other medication, will I be okay or can there be massive shedding? I recall there was…"
""You think those supplements+Litfulo can help?"
-If JAK will not work supplement will not help it just small addition that will speed up the process, Liftulo is the worse JAK.
"You use any of those?"
-No I dont.
"I see…"
"I dont have experience with Latisse so I cant say anything.
Curcumin (Turmeric extract) and Resveratrol can inhibit related ILs but I dont think that effect will be strong to give results alone.
Also anti-derpessants such as Lexapro and…"
"I reply here to your reply from 20 August because I cant do that below original post.
"I wonder if the side effects of Leqselvi 8mg vs Olumiant 4 mg are better or worse. "
Here are results of clinical trials of CTP-543 (Leqselvi) with…"
"What actually matters is inhibiton of Interleukins (ILs) by blocking JAK-STAT pathway implicated in AA such as IL-6, IL-15, IL-17, INFy. JAK2 can also block some of them (look at screenshot with JAKs that I posted very early). It very individual…"
"Yes, I was on 50mg of Litfulo it was revealed to me in extension phase of clinical trial when I participated.
Here is comparison of effectivness of JAKs inhibitors in AA.
CTP-543 is Lesqelvi which is deuterated version of ruxolitinib. I took…"
"Here is peer-reviewed study that showed one patient that was unresponsive to Baricitinib but respondend to Upadacitinib:
https://www.tandfonline.com/doi/full/10.1080/09546634.2024.2304630
Also as I mentioned before, I was unresponded for Litfulo…"
"Hey, sorry for late reply.
I cannot afford JAKis so I participated in clinical trials where I have it for free - Baricitinib in clinical trials is not available for me.
For me Litfulo was the worse I had almost zero effects from it.
The best was…"
"Baricitinib is JAK1/JAK2 inhibitor and 4mg of it in clinical trials showed supperior efficacy compared to ritlecitinib and tofacitinib. I took Litfulo 50mg (JAK3), Leqselvi 12mg in clinical trials (JAK1/JAK2) and right now I'm taking Rinvoq…"
"Tofacitinib doesnt target exactly the same pathway as Ritlecitinib. Tofacitinib works broader by inhibiting JAK1/JAK3 an partially JAK2, RItlecitinib works only on JAK3, so there is possibility that results not will be maintain sadly during…"
Upadacitinib provides great results refractory to other JAKs.
Hi.Im aleopacia patient that participated in ritlecitinib, deuruxolitinib and upadacitinib studies. Upadacitinib gives effects in cases refractory to other medicines also inclusion of antidepressants maybe helpful. I've made article about it. Please read it. https://www.patreon.com/posts/119627390See More
"Hello.
If you want to know pf-06651600 did not work for me, and surely I wasnt on placebo, my dose was probably 50 mg which is the highest. But after that I enrolled into CTP 543 trial and I have significant regrowth so dont worry if one of…"
"Thanks for the info. Which of the tablets tasted different before extension? I though that if it is lower dose then the one of this 10 mg tablets (the little ones) should taste bitter, but now I have the bigger one bitter. I'm thinking about…"
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