All Discussions Tagged 'research' - Alopecia World2024-03-28T21:31:21Zhttps://alopeciaworld.com/forum/topic/listForTag?tag=research&feed=yes&xn_auth=noOff-Label Tofacitinib in Ireland?tag:alopeciaworld.com,2019-05-12:2022678:Topic:14759842019-05-12T22:08:09.800Zhellopeeshahttps://alopeciaworld.com/profile/hellopeesha
<p>Hey,</p>
<p>I'm based in Ireland and am hoping to order tofacitinib from overseas soon, as the price is horrendous here.</p>
<p>However, I'm wondering how it would work getting a prescription/medical supervision while I take it.</p>
<p>Is it within my doctor's rights to prescribe me tofacitinib off-label? Tofacitinib is only approved in Ireland for treatment of arthritis at the moment, but I'm wondering how the whole off-label part works...</p>
<p>Thanks…</p>
<p>Hey,</p>
<p>I'm based in Ireland and am hoping to order tofacitinib from overseas soon, as the price is horrendous here.</p>
<p>However, I'm wondering how it would work getting a prescription/medical supervision while I take it.</p>
<p>Is it within my doctor's rights to prescribe me tofacitinib off-label? Tofacitinib is only approved in Ireland for treatment of arthritis at the moment, but I'm wondering how the whole off-label part works...</p>
<p>Thanks guys!</p>
<p>Paul.</p>
<p></p>
<p><span>-----------------------------</span></p>
<p><strong>AW: Other discussions on Tofacitinib</strong></p>
<p><a href="https://alopeciaworld.com/main/search/search?q=Tofacitinib">https://alopeciaworld.com/main/search/search?q=Tofacitinib</a></p> GLANDULAR EXTRACTStag:alopeciaworld.com,2018-09-24:2022678:Topic:14286032018-09-24T10:36:50.018ZDanhttps://alopeciaworld.com/profile/Dan834
<p>Hey,</p>
<p>I was recently looking to find out which gland effects alopecia and cant find anything on the subject. I know that with autoimmune diseases you can take an animal extract of the gland causing the problem, for example, if you have a thyroid problem, you can take thyroid extract to divert your immune system from attacking your thyroid and give your body time to heal. So, my question is, what glad or system effects alopecia so I can know what extract to take?</p>
<p>Danny </p>
<p>Hey,</p>
<p>I was recently looking to find out which gland effects alopecia and cant find anything on the subject. I know that with autoimmune diseases you can take an animal extract of the gland causing the problem, for example, if you have a thyroid problem, you can take thyroid extract to divert your immune system from attacking your thyroid and give your body time to heal. So, my question is, what glad or system effects alopecia so I can know what extract to take?</p>
<p>Danny </p> Scientists obtain 'how to' guide for producing hair folliclestag:alopeciaworld.com,2017-08-13:2022678:Topic:13891782017-08-13T10:48:51.948Zrj, Co-founderhttps://alopeciaworld.com/profile/rj
<p><a href="http://stemcell.usc.edu/2017/08/11/usc-stem-cell-scientists-obtain-how-to-guide-for-producing-hair-follicles/" target="_blank"><img alt="Two types of progenitor cells from dissociated skin—epidermal (green) and dermal (red)—undergo a series of morphological transitions to form reconstituted skin. (Images by Mingxing Lei/Cheng-Ming Chuong Lab)" class="align-right" src="http://storage.ning.com/topology/rest/1.0/file/get/2059819440?profile=RESIZE_320x320" width="300"></img></a> How does the skin develop follicles and eventually sprout hair? A USC-led study, published in the Proceedings of the National Academy of Sciences (PNAS), addresses this question using insights gleaned from organoids, 3D assemblies of cells possessing rudimentary skin structure and function—including the ability to grow hair.</p>
<p>In the…</p>
<p><a href="http://stemcell.usc.edu/2017/08/11/usc-stem-cell-scientists-obtain-how-to-guide-for-producing-hair-follicles/" target="_blank"><img width="300" src="http://storage.ning.com/topology/rest/1.0/file/get/2059819440?profile=RESIZE_320x320" class="align-right" alt="Two types of progenitor cells from dissociated skin—epidermal (green) and dermal (red)—undergo a series of morphological transitions to form reconstituted skin. (Images by Mingxing Lei/Cheng-Ming Chuong Lab)" width="300"/></a>How does the skin develop follicles and eventually sprout hair? A USC-led study, published in the Proceedings of the National Academy of Sciences (PNAS), addresses this question using insights gleaned from organoids, 3D assemblies of cells possessing rudimentary skin structure and function—including the ability to grow hair.</p>
<p>In the study, first author Mingxing Lei, a postdoctoral scholar in the USC Stem Cell laboratory of Cheng-Ming Chuong, and an international team of scientists started with dissociated skin cells from a newborn mouse. Lei then took hundreds of timelapse movies to analyze the collective cell behavior. They observed that these cells formed organoids by transitioning through six distinct phases: 1) dissociated cells; 2) aggregated cells; 3) cysts; 4) coalesced cysts; 5) layered skin; and 6) skin with follicles, which robustly produce hair after being transplanted onto the back of a host mouse.</p>
<p>In contrast, dissociated skin cells from an adult mouse only reached phase 2—aggregation—before stalling in their development and failing to produce hair.</p>
<p>To understand the forces at play, the scientists analyzed the molecular events and physical processes that drove successful organoid formation with newborn mouse cells.</p>
<p>“We used a combination of bioinformatics and molecular screenings, and the core facilities at the Health Sciences Campus have facilitated my analyses,” said Lei.</p>
<p>At various time points, they observed increased activity in genes related to: the protein collagen; the blood sugar-regulating hormone insulin; the formation of cellular sheets; the adhesion, death or differentiation of cells; and many other processes. In addition to determining which genes were active and when, the scientists also determined where in the organoid this activity took place. Next, they blocked the activity of specific genes to confirm their roles in organoid development.</p>
<p>By carefully studying these developmental processes, the scientists obtained a molecular “how to” guide for driving individual skin cells to self-organize into organoids that can produce hair. They then applied this “how to” guide to the stalled organoids derived from adult mouse skin cells. By providing the right molecular and genetic cues in the proper sequence, they were able to stimulate these adult organoids to continue their development and eventually produce hair. In fact, the adult organoids produced 40 percent as much hair as the newborn organoids—a significant improvement.</p>
<p>“Normally, many aging individuals do not grow hair well, because adult cells gradually lose their regenerative ability,” said Chuong, senior author, USC Stem Cell principal investigator and professor of pathology at the Keck School of Medicine of USC. “With our new findings, we are able to make adult mouse cells produce hair again. In the future, this work can inspire a strategy for stimulating hair growth in patients with conditions ranging from alopecia to baldness.”</p>
<p>Additional co-authors include: Chao-Yuan Yeh, Ping Wu, Ting-Xin Jiang, and Randall Bruce Widelitz from USC; Linus J. Schumacher from the University of Oxford and Imperial College, London; Ruth E. Baker from the University of Oxford; Yung-Chi Lai from China Medical University; Wen-Tau Juan from China Medical University and Academia Sinica, Taipei; and Li Yang from Chongqing University.</p>
<p>Most of the experimental work was supported by U.S. federal funding from the National Institutes of Health (AR42177 and AR60306). The multi-disciplinary team members were also supported by nine non-U.S. sources: the China Postdoctoral Science Foundation (2016M590866); Fundamental Research Funds for the Central Universities (106112015CDJRC231206); Special Funding for Postdoctoral Research Projects in Chongqing (Xm2015093); the China Scholarship Council (2011605042); the Innovation and Attracting Talents Program for College and University (111 project grant B06023); the National Nature Science Foundation of China (11532004 and 31270990); the Academia Sinica Research Project on Nanoscience and Technology; the Ministry of Science and Technology of Taiwan; and the UK Engineering and Physical Sciences Research Council (EP/F500394/1).</p>
<p><strong>SOURCE</strong>: <a href="http://stemcell.usc.edu/2017/08/11/usc-stem-cell-scientists-obtain-how-to-guide-for-producing-hair-follicles/" target="_blank">University of Southern California</a></p> AA Market Research: Paid Parent Interviews in Chicagoland and Philadelphia July 10-14, 2017tag:alopeciaworld.com,2017-07-02:2022678:Topic:13820602017-07-02T14:55:27.057ZSpenserhttps://alopeciaworld.com/profile/Spenser
<p><span> Chicagoland and Philadelphia "Alopecia Parents/caregivers": Your feedback needed!</span></p>
<p></p>
<p><span>Got a child 13-17 with moderate to severe AA/AT/AU or atopic dermatitis diagnosed more than a year ago?</span></p>
<p><span>Be interviewed in person July 10/11 (Philly) or July 13/14 (Chicago) for alopecia areata market research and get paid $150 for your time. </span></p>
<p></p>
<p><span>To get an appt, mention Bald Girls Do Lunch as referral (I work as research outreach…</span></p>
<p><span> Chicagoland and Philadelphia "Alopecia Parents/caregivers": Your feedback needed!</span></p>
<p></p>
<p><span>Got a child 13-17 with moderate to severe AA/AT/AU or atopic dermatitis diagnosed more than a year ago?</span></p>
<p><span>Be interviewed in person July 10/11 (Philly) or July 13/14 (Chicago) for alopecia areata market research and get paid $150 for your time. </span></p>
<p></p>
<p><span>To get an appt, mention Bald Girls Do Lunch as referral (I work as research outreach intern for BGDL support nonprofit) and send email to Research.Opportunity@schlesingerassociates.com or call 215.734.9496 and ask for Morgan Hassig.</span></p>
<p></p>
<p></p> Medication-induced alopeciatag:alopeciaworld.com,2016-12-20:2022678:Topic:13491492016-12-20T19:25:56.465Zhersheys123https://alopeciaworld.com/profile/hersheys123
<p>Hello all. I am a bit scared here. I am 31 and was on some prescribed medication for a few weeks when my partner and i started noticing hair all over the house. I was in denial for a while but then I started to see extreme thinning and some bald spots on the back of my head. Yesterday I went to the dermatologist who diagnosed me with Alopecia areata. I have discontinued the medication immediately, but the hair continues to fall. I was given clobetasol, which I've just started applying. I was…</p>
<p>Hello all. I am a bit scared here. I am 31 and was on some prescribed medication for a few weeks when my partner and i started noticing hair all over the house. I was in denial for a while but then I started to see extreme thinning and some bald spots on the back of my head. Yesterday I went to the dermatologist who diagnosed me with Alopecia areata. I have discontinued the medication immediately, but the hair continues to fall. I was given clobetasol, which I've just started applying. I was also told to use various dandruff shampoos and switch them around to fool the follicles. </p>
<p>I had long hair down to my hips, but now I have to cut it short, the doctor said. It took me years to grow out. </p>
<p>I am asking for some support here, first of all, as in, any recommendations or anyone relate?</p>
<p>I am also asking what kinds of hats you guys like, because I'm going to need some hats. </p> What causes alopecia? Any new news?tag:alopeciaworld.com,2016-10-12:2022678:Topic:13411982016-10-12T06:30:17.012ZMineahttps://alopeciaworld.com/profile/Merit
<p>Hiya all!</p>
<p>I notice that when asked about my alopecia I tend to talk about how its an autoimmune disease and that we don't really know where it comes from. It's only caused by stress to the point that stress can trigger it, but you have to have alopecia for it to be triggered. Most likely it is hereditary but we don't know how commonly so.</p>
<p>I have said this for the last 15 years and now I realize that this might all be quite dated information. Has more happened in alopecia…</p>
<p>Hiya all!</p>
<p>I notice that when asked about my alopecia I tend to talk about how its an autoimmune disease and that we don't really know where it comes from. It's only caused by stress to the point that stress can trigger it, but you have to have alopecia for it to be triggered. Most likely it is hereditary but we don't know how commonly so.</p>
<p>I have said this for the last 15 years and now I realize that this might all be quite dated information. Has more happened in alopecia research? Do we know more of how you get it? And if so, would anyone be able to to point me to good articles about this.</p>
<p>Thank you for your help!</p>
<p>Merit</p> A ray of hope for alopecia areata patientstag:alopeciaworld.com,2016-06-08:2022678:Topic:13257792016-06-08T04:22:39.719Zrj, Co-founderhttps://alopeciaworld.com/profile/rj
<p>This from the Royal Pharmaceutical Society's <em>Pharmaceutical Journal</em>, May 10, 2016:</p>
<blockquote><p>"There are no clinically proven treatments. However, this bleak clinical picture could be about to change as genetic discoveries point the way to new drug targets. But companies with the financial clout to make a difference need to do the necessary clinical trials if new treatments are to be licensed."…</p>
</blockquote>
<p></p>
<p>This from the Royal Pharmaceutical Society's <em>Pharmaceutical Journal</em>, May 10, 2016:</p>
<blockquote><p>"There are no clinically proven treatments. However, this bleak clinical picture could be about to change as genetic discoveries point the way to new drug targets. But companies with the financial clout to make a difference need to do the necessary clinical trials if new treatments are to be licensed."</p>
</blockquote>
<p><a href="http://www.pharmaceutical-journal.com/news-and-analysis/features/finding-new-treatments-for-alopecia-areata-patients/20201092.article" target="_blank">Click here</a> to read the entire article, which discusses several "promising treatments."</p> Alopecia research in DC and NEW YORKtag:alopeciaworld.com,2016-01-04:2022678:Topic:12953242016-01-04T08:19:14.013Zocbohttps://alopeciaworld.com/profile/ocbo
<p>Hi! I'm Egle, I'm from Lithuania and I have AA. I'm scientist.</p>
<p>I"m going visit USA <span class="hps">to acquire</span><span> </span><span class="hps">professional</span><span> </span><span class="hps">experience with Alopecia ( from science view) to help my people with alopecia in my country. </span></p>
<p><span class="hps">And I need your help: I'm looking for my internship place in DC or NEW YORK. I already found <span>Columbia University Medical Center , where…</span></span></p>
<p>Hi! I'm Egle, I'm from Lithuania and I have AA. I'm scientist.</p>
<p>I"m going visit USA <span class="hps">to acquire</span><span> </span><span class="hps">professional</span><span> </span><span class="hps">experience with Alopecia ( from science view) to help my people with alopecia in my country. </span></p>
<p><span class="hps">And I need your help: I'm looking for my internship place in DC or NEW YORK. I already found <span>Columbia University Medical Center , where <span>researchers</span> already works with A. Maybe you can advise another places for my internship ( where working with alopecia)? </span></span></p>
<p></p>
<p><span class="hps"><span>I'll be very grateful :))</span></span></p> Has anyone on here tried the ruxolitinib medication also a JAK inhibitor?tag:alopeciaworld.com,2015-05-19:2022678:Topic:12589972015-05-19T16:37:27.824Zblondfroghttps://alopeciaworld.com/profile/blondfrog
<p>They have began trials in 2013 of August and are ending the trials this year in 2015 of August. Just wondering cause I keep reading on here about the Xelnajz trial drugs only. Doctor Christiano and Kines and her research team tried these drugs on mice and 3 humans and all 3 should 100% hair restoration. </p>
<p><a href="https://clinicaltrials.gov/ct2/show/NCT01950780">https://clinicaltrials.gov/ct2/show/NCT01950780…</a></p>
<p></p>
<p>They have began trials in 2013 of August and are ending the trials this year in 2015 of August. Just wondering cause I keep reading on here about the Xelnajz trial drugs only. Doctor Christiano and Kines and her research team tried these drugs on mice and 3 humans and all 3 should 100% hair restoration. </p>
<p><a href="https://clinicaltrials.gov/ct2/show/NCT01950780">https://clinicaltrials.gov/ct2/show/NCT01950780</a></p>
<p><a href="https://www.youtube.com/watch?v=nWXMIAEEl2g&index=32&list=LLGTVz4kWVh7t4DhpxEiH2dQ">https://www.youtube.com/watch?v=nWXMIAEEl2g&index=32&list=LLGTVz4kWVh7t4DhpxEiH2dQ</a></p>
<p>Also if you are please share you story and if they do approve it do you think they should approve it in cream form or oral?</p> Don't want to jinx myself but....tag:alopeciaworld.com,2015-01-28:2022678:Topic:12399812015-01-28T19:54:03.300ZHairJourneyhttps://alopeciaworld.com/profile/HairJourney
I am a 27 year old female and have had Alopecia Areata since November 2013. In January 2015, after months of heartache and going through an abundance of hair loss products, I made the decision to try another form of treatment. I have been receiving treatments from my dermatologist for a month now and see GROWTH! I did 1 round of kenalog injections on 1/6/2015 and have been using low-level laser therapy for a month. I am beginning to see a huge difference in one of my patches in just a month.…
I am a 27 year old female and have had Alopecia Areata since November 2013. In January 2015, after months of heartache and going through an abundance of hair loss products, I made the decision to try another form of treatment. I have been receiving treatments from my dermatologist for a month now and see GROWTH! I did 1 round of kenalog injections on 1/6/2015 and have been using low-level laser therapy for a month. I am beginning to see a huge difference in one of my patches in just a month. Has anyone else had luck with low-level laser therapy! I will be uploading photos to my profile as well as my blog brittshairjourney.WordPress.com