Hope!

Hey all, I live in Australia and was watching the news and an Australian Universaty has just discovered the gene that causes auto immune disorders. The
next step is human trials to switch it of and treat a whole array of immune conditions. Sounds promising !!

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Permalink Reply by Sav Cavarretta on November 3, 2011 at 11:54pm
yeah i think i would be a shaggy dog too for a while!
Permalink Reply by Margie Jelar on November 4, 2011 at 4:11pm
AND THEN DONATE TO lOCKS OF lOVE-NEVER FORGET WHERE WE HAVE COME FROM WITH THIS DISEASE!!
and CANCER MAY STILL BE OUT THERE FOR THOSE VICTIMS STILL NEEDING WIGS...
Permalink Reply by Bald and Fabulous AKA Terri on November 3, 2011 at 12:46pm
figuring out the trigger to one autoimmune disease will have a snowball effect to others.....very promising
Permalink Reply by Fulvio982 on November 3, 2011 at 1:46pm
Yeah, promising but it always seems to be future possible developments.. but we never see some real promise, real timelines.. real future I mean.
Permalink Reply by Tony J. on November 3, 2011 at 5:39pm
Here are two interesting studies from the University of Miami Miller School of Medicine. Keep in mind these are mouse studies and no human studies have been done in this directions so far.

Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model.
http://www.ncbi.nlm.nih.gov/pubmed/20582641

Abstract

Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. Previous studies have demonstrated an association between AA and physiological/psychological stress. In this study, we investigated the effects of heat treatment, a physiological stress, on AA development in C3H/HeJ mice. Whereas this strain of mice are predisposed to AA at low incidence by 18 months of age, we observed a significant increase in the incidence of hair loss in heat-treated 8-month-old C3H/HeJ mice compared with sham-treated mice. Histological analysis detected mononuclear cell infiltration in anagen hair follicles, a characteristic of AA, in heat-treated mouse skin. As expected, increased expression of induced HSPA1A/B (formerly called HSP70i) was detected in skin samples from heat-treated mice. Importantly, increased HSPA1A/B expression was also detected in skin samples from C3H/HeJ mice that developed AA spontaneously. Our results suggest that induction of HSPA1A/B may precipitate the development of AA in C3H/HeJ mice. For future studies, the C3H/HeJ mice with heat treatment may prove a useful model to investigate stress response in AA.

Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model.
http://www.ncbi.nlm.nih.gov/pubmed/22042611

Abstract

Alopecia areata (AA) is an autoimmune non-scarring hair loss disorder. AA can be acute, recurrent, or chronic. Current therapeutic options for AA are limited, and there is no effective prevention for recurrent AA. We have previously shown a correlation between the expression of HSP70 (HSPA1A/B), a heat shock protein involved in the inflammatory response, and the onset of AA in the C3H/HeJ mouse model. In this study, we tested the effects of quercetin, a bioflavonoid with anti-inflammatory properties, on AA development and HSP70 expression in the C3H/HeJ model. Mice with spontaneous AA were treated with subcutaneous quercetin or sham injections. Hair regrowth was observed in lesional areas in all the quercetin-treated mice, but in none of the sham-treated mice. In addition, non-alopecic C3H/HeJ mice were heat-treated to induce alopecia, along with quercetin or sham injections. Whereas 24% of the heat-treated mice with sham injections developed alopecia, none of the mice receiving quercetin injections did. As expected, the level of HSP70 expression in quercetin-treated areas was comparable to control. Furthermore, we showed that systemic delivery of quercetin by intraperitoneal injections prevented/reduced spontaneous onset of AA. Our results demonstrated that quercetin provided effective treatment for AA as well as prevention of onset of AA in the C3H/HeJ model, and warrant further clinical studies to determine whether quercetin may provide both treatment for preexisting AA and prevention of recurrent AA. The ready availability of quercetin as a dietary supplement may lead to increased patient compliance and positive outcomes for AA.
Permalink Reply by Leslie Mader on November 5, 2011 at 12:41pm
Hope research continues!
Permalink Reply by Jarod on November 5, 2011 at 8:39pm
Wow that sounds really interesting! If you get any more info on it be sure to let us know
Permalink Reply by samantha on November 7, 2011 at 4:51am
yay!im part of the registry they can use me:) lol
Permalink Reply by Margie Jelar on November 7, 2011 at 8:34am
Alopecia Awareness Contest at My FB page: Margie Jelar (Mueller)





November 6, 2011 at 6pm to December 15, 2011 at 7pm

Alopecia Awareness Contest..getting the WORD OUT with Media attention!One click voting to spread the word..Details on FB-Friend me for details..(it won't let me add the direct link to the contest page-tried for 2 days now-i surrender!)
Permalink Reply by pex7 on November 8, 2011 at 5:56pm
I have had alopecia since 1995, for the longest time doctors and scientists were clueless. Now just in the past year or so there has been many huge discoveries. I read about Dr. Christiano's research at naaf website, and this study looks promising also. I wondered for a long time if they would find a cure during my lifetime. At this point I believe they will!
Permalink Reply by Margie Jelar on November 14, 2011 at 6:33pm

OMG lets hope so..can you image...

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