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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by kevin on
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not to worry, it is in patients over 50 years old with cardiovascular risks, and it is only xeljanz that is threatened. the other jak inhibitors tested passed the safety profiles
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Hi Kevin, mostly I’m on 15 mg these days, I drop to 10 mg when life is pretty stable and health good, but up it when stressful occurrence happen, mainly cause those tend to trigger flares in my hashimotos (I feel hot all the time, lose weight etc) and that has been when historically my Alopecia had hit, but so far no sheds even on 10 mg. My mother is sick at the moment so I am back to 15 for awhile. I hope to get to 5 mg eventually but no hurry. Blood work all good and feel really healthy. I don’t think they are gonna take jak inhibitors out of the market place given its successful use for so many conditions but I think it might slow down FDA approval for other conditions like Alopecia. Your insight, through discussions with your specialist, will be interesting to hear. I hope you area well! It’s been a crazy 12 months for the world
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I have a friend who is going to participate in the phase 3 clinical trial of ctp 543 in paris in france and myself at that of pf pfizer I read that there was no serious event, and it is the last phase before placing on the market.
I see my dermatologist tomorrow I will talk to him about it
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Can you please please update us after you see your derm? Please don't forget
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Which jak inhibitor do you take?
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Any idea when jak inhibitors will be approved?
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you have 2 jaks for alopecia in clinical trials the ctp 543 in phase 3 scheduled for 2023 and the Pfizer pf according to my dermatologist 2024 2025 if it meets the criteria of safety and efficacy those they have achieved phase 2.
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Correct me if I am wrong but Lilly has a Jak(Baricitinib) in phase 3 trials for Alopecia as well.
Also while not a Jak, Arena Pharmaceuticals has a drug Etrasimod in phase 2.
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hi indeed but it will not be approved because of side effects like xeljanz, the only ones that will be approved will be ctp 543
and pf from pfizer because it is only for alopecia and it targets fewer enzymes so fewer side effects and it is a better option for long term use
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Thanks Kevin what is pf?
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