""My concern is that I need Jak 1 and 3 blocked, but there is no medicationt that does that concentrated, right? Litfulo was supposed to be, but they stopped it do to safety concerns it seems like. "
JAK3 is blocking same cytokines (ILs)…"
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Eldonimo
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Doctor wants to switch me from Tofacitinib to Ritlecitinib (Litfulo)
Started this discussion. Last reply by tomasz777321 yesterday. 29 Replies 0 Likes
Hello everyone. My doctor advised to change medications as seen from the title. I’ve had full regrowth on Tofacitinib with spots here and there mostly on my facial hair. I’ve had a very bad flare up…Continue
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"@tomasz
I am not on a break and never taken a break since 2018
I was on Xeljanz from 2018-2019 on standard dosage (full year). Grew nothing, so I went to double dose for a while. Grew back probably 1/2-2/3 of my hair, all my eyelashes, most of…"
"@tomasz
I am not on a break and never taken a break since 2018
I was on Xeljanz from 2018-2019 on standard dosage (full year). Grew nothing, so I went to double dose for a while. Grew back probably 1/2-2/3 of my hair, all my eyelashes, most of…"
"@nhazir
I dont know your disease history. Do you have any break of treatment and when did that occur? What JAK you tried before Litfulo. If you are currently sheeding on Litfulo 50mg and you didnt have any break of treatment then I would switch to…"
""-I thought you have AU and zero hairs. If you have small bald spots then this might support immunosupression of JAK inhibitors."
I had Alopecia with 1 patch in 2016-2018, then I had AU. What is it considered now if I have my beard,…"
"I can also look to switch to Baricitnib/Leqselvi, but worried it also doesnt work. Also worried about the time from when I am off of Litfulo and just starting the other medication, will I be okay or can there be massive shedding? I recall there was…"
"So Egcg definitely helped my beard about 4-5 years ago, but I was also in the phase of growing and not shedding. Guess it cant hurt to try these+Litfulo, but unsure what I should be doing honestly.
I can also look to switch to…"
""You think those supplements+Litfulo can help?"
-If JAK will not work supplement will not help it just small addition that will speed up the process, Liftulo is the worse JAK.
"You use any of those?"
-No I dont.
"I see…"
"You think those supplements+Litfulo can help?
I took RSV for some months, but would upset my stomac iirc.
I feel like Curcumin will do the same, but not sure
You use any of those?
I see that Leqselvi 8mg is twice a day....so isnt that…"
"I dont have experience with Latisse so I cant say anything.
Curcumin (Turmeric extract) and Resveratrol can inhibit related ILs but I dont think that effect will be strong to give results alone.
Also anti-derpessants such as Lexapro and…"
"When you said you were taking 12mg twice daily, did you mean
24mg total or 6mg each time?
The studies for Leqselvi didnt really mention many people on adverse side effects. Am I missing this?
Do you know of any supplements that block Jak 1…"
"I reply here to your reply from 20 August because I cant do that below original post.
"I wonder if the side effects of Leqselvi 8mg vs Olumiant 4 mg are better or worse. "
Here are results of clinical trials of CTP-543 (Leqselvi) with…"
"Ah I always thought 8mg of Baricitnib was available or mabe I had read some stories of people taking it for a short time
Does anyone here/that you know of take Leqselvi 12mg for even a short time?
I wonder if the side effects of Leqselvi 8mg vs…"
"What actually matters is inhibiton of Interleukins (ILs) by blocking JAK-STAT pathway implicated in AA such as IL-6, IL-15, IL-17, INFy. JAK2 can also block some of them (look at screenshot with JAKs that I posted very early). It very individual…"
"Thanks for the last post, I couldnt reply to it there so replying in two spots
Leqselvi 12mg shows better than Olumiant 8mg no?
I thought Leqselvi should be better since it targets Jak2 less. Am I wrong on this?
Also what does this mean "but…"
"Yes, I was on 50mg of Litfulo it was revealed to me in extension phase of clinical trial when I participated.
Here is comparison of effectivness of JAKs inhibitors in AA.
CTP-543 is Lesqelvi which is deuterated version of ruxolitinib. I took…"
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