Isoprinosine

Anyone heard of this for treating AU? I just saw it on another board and did a pub med search and it didnt seem all that bad. Some studies are not good but others are positive. Its an old drug, I wonder why I never hear about it. examplefrom pub med:

J Am Acad Dermatol. 1985 Jan;12(1 Pt 1):78-84.

Clinical and immunologic response to Isoprinosine in alopecia areata and alopecia universalis: association with autoantibodies.
Lowy M, Ledoux-Corbusier M, Achten G, Wybran J.

Abstract
Twenty patients with alopecia universalis, alopecia semiuniversalis and alopecia areata were studied for their immune parameters. Fourteen of them received an oral treatment with Isoprinosine, a synthetic immunomodulator. Ten patients showed the presence of several autoantibodies. No significant abnormalities in various T cell rosette markers were found, but T4/T8 ratios tended to be elevated. Erythrocyte antibody complement (EAC) rosettes were usually decreased. Treatment with Isoprinosine produced a clinical response, as judged by total or partial hair growth, in nine of the fourteen patients treated. It was striking to observe that seven of the nine responders had autoantibodies prior to treatment. These autoantibodies disappeared or decreased with Isoprinosine therapy. In contrast, only one of five nonresponders had serum autoantibodies. After treatment, both groups showed an increase in blood-active T rosettes. These results suggest that alopecia is a heterogeneous disease subdivided by the presence or absence of autoantibodies since clinical response was mainly obtained in patients presenting autoantibodies.

PMID: 2579988 [PubMed - indexed for MEDLINE]


Publication Types, MeSH Terms

Views: 383

▶ Reply to This

Replies to This Discussion

Permalink Reply by Marisa on August 14, 2010 at 8:58pm
I have not heard of this but just sent this to my doctor to see if she has. Interested to find out if anyone has tried this. After reading some of the posts on gluten free, casin free diets I think I am going to give that a shot.....Where can I find out more about this..thanks.
Permalink Reply by divine_comedy on June 15, 2012 at 8:58am

I'm starting this medication, let's see...

Permalink Reply by Amy on July 30, 2012 at 4:11pm

any update?

Permalink Reply by divine_comedy on July 30, 2012 at 4:30pm

Not yet, nothing changed so far...

Permalink Reply by Scott James on July 31, 2012 at 5:43pm

Any side effects to taking this drug ?

Looks like the Isoprinosine study mentioned in this report (page 6) saw complete remission at 12 weeks in 50% of patients taking this drug.

Permalink Reply by divine_comedy on August 1, 2012 at 3:46am

Yes, I've posted the original study in another post. This Friday I'll reach 1 month and 3 weeks, so maybe that explains why there are no good news yet, or maybe I'm just not lucky. It seems that a particular group of people would be more prone to be treated this way.

Still, there are no side effects, it's a very safe drug. There's no problem in trying. Just print out the original paper and ask your doctor to start the treatment. Look for my other post on this. And keep us posted on the results :p

Permalink Reply by Scott James on August 22, 2012 at 6:22pm

Hi divine_comedy

How are you getting on with the Isoprinosine ?

Permalink Reply by divine_comedy on August 23, 2012 at 4:26am

All is fine except that no hair is growing. The "experiment" will stop in one month. The dose is high but it could be that it's not enough. Or maybe it needs more time... Or maybe it just doesn't work with me. But I recommend people to try, it's a bit costly but good results have been achieved before.

Permalink Reply by Scott James on August 24, 2012 at 4:38am

Worth a shot definitely

Permalink Reply by Jonathan on November 18, 2016 at 10:46pm

Hi everyone:

My name is Jonathan, I`m new in this website.

I`m with AT almost 4 month ago but my first experience with AA when i was 10 years old (now im 29).

I visited a doctor (dermatologist) and he wanna try with isoprosine,

i have taking this drug for nine days and i see a little change on my hair (it is growing).

So.. i dont know much about this drug or side effects.

somebody take this drug? ... or know about other cases.

Thanks for reading.

p.d: Sorry, my english its very bad, I`m a spanish speaker.

RSS

Disclaimer

Any mention of products and services on Alopecia World is for informational purposes only; it does not imply a recommendation or endorsement by Alopecia World. Nor should any statement or representation on this site be construed as professional, medical or expert advice, or as pre-screened or endorsed by Alopecia World. Alopecia World is not responsible or liable for any of the views, opinions or conduct, online or offline, of any user or member of Alopecia World.

© 2024   Created by Alopecia World.   Powered by

Badges  |  Report an Issue  |  Terms of Service