Mannose-binding lectin (MBL) deficiency. Is there any link with alopecia?

Hi folks,

I recently was hospitalised with a one off case of septic arthritis and went to see a rheumatologist who carried out a series of blood tests on me. I have Alopecia Universalis over 7 years now and other then seeing a dermatologist once or twice never really looked into my Alopecia medically. It so happens that during these blood tests it was discovered that I was MBL deficient, Mannose Binding Lectin which is protein that everybody has, and is an innate immune response which forms a first line of defence against infection. Basically it is a fundamental component and a first line of defence in your immune system which locks onto invading bodies to allow the bodies defences to recognise them and deal with them.

A deficiency in this is not common and my rheumatologist was interested in the fact that I had this autoimmune condition (AU) and that he happened to characterise the fact that I was also MBL deficient, an autoimmune deficiency.

I was wondering if anybody else has ever been characterised with this, or if they are getting any blood tests, to enquire with their physician if they could get tested to see if they are MBL deficient. Because the number of people in the population with Alopecia is so small, and the number tested or characterised with MBL is also very small it may have gone un-noticed if there was any link between the two, as its not possible to conduct group studies on such isolated occurances.

There may be absolutely no link and not related to Alopecia but if anybody with Alopecia has themselves tested for MBL deficiency ( a realtively inexpensive blood test) and the result comes back positive please get your physician to forward the results and the fact its related to an Alopecian to Dr Graeme Carroll (Perth WA) who identified this MBL deficiency in me on: secretary@arthrocare.com.au

Please do not personally contact his office regarding general Alopecia enquiries as he is a very busy practicioner and is not a dermatologist.

Also let me know on here if you happen to have Alopecia and are also MBL deficient.

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