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NAAF: FDA-approved drug produces near complete hair regrowth
The National Alopecia Areata Foundation congratulates its advisors, Drs. Raphael Clynes (center), Angela Christiano (right) and Julian Mackay-Wiggan (left), and their team at Columbia University Medical Center for their exciting preliminary findings with an FDA-approved drug which has produced near complete hair regrowth in several patients with moderate-to-severe alopecia areata. We applaud the publication of these results in Nature Medicine this month.
This triumph is the result of a long history of Genome Wide Association Studies conducted by Dr. Christiano and supported by NAAF with well-characterized samples from the Registry, Biobank and Clinical Trials Network, a key component of our Alopecia Areata Treatment Development Program. This earlier groundbreaking research, which was published in Nature in 2010, established the genetic basis for alopecia areata, revealing underlying autoimmune mechanisms that contribute to the disease.
The genetic studies provided the clue that led to rationally selecting the Janus Kinase (JAK) pathways as a target for treatment. In a cutting-edge immunology research effort led by Dr. Clynes, the team has since performed multiple studies testing JAK inhibitors and demonstrating efficacy in animal models, and this work is now culminating in pilot studies of two FDA-approved drugs in small patient populations. The Columbia Team plans to launch additional clinical studies to further investigate these findings. Click here to learn more.
While the results are encouraging, we wish to remind the alopecia areata community this is a preliminary study in a small population. Larger, more robust clinical trials are necessary to fully evaluate safety, efficacy and durability. JAK inhibitors as a class of drugs are potent immunosuppressive agents, and in patients with underlying diseases, have been associated with significant side effects. These adverse effects may be less commonly seen in alopecia areata patients, who in general are otherwise healthy.
The importance of the Alopecia Areata Registry, Biobank and Clinical Trials Network (Registry) is demonstrated by the valuable research of Dr. Christiano, who received crucial early grant support from NAAF for the genetic studies. Along with Drs. Clynes and Mackay-Wiggan, members of the Columbia team have been active participants in the NAAF Research Summits aimed at developing new treatments. Without quick and easy access to well-characterized samples through the Registry – and the strategic framework of the Alopecia Areata Treatment Development Program and associated Research Summits – these breakthroughs would never have been realized in only a few short years. If you would like to help with future clinical trials, please join the Registry and add to our nearly 10,000 registrants.
There are currently 6.5 million people in the US that have, had, or will have alopecia areata in their lifetime and over 145 million worldwide. As Dr. Christiano knows firsthand from her own personal experience with the disease, alopecia areata is too often dismissed as simply an appearance-altering disease. “Nothing could be further from the truth,” she said in a recent statement at Columbia University. “Patients with alopecia areata are suffering profoundly, and these findings mark a significant step forward for them. The team is fully committed to advancing new therapies for patients with a vast unmet need.”
For more information about how NAAF plans to support this exciting research through our Alopecia Areata Treatment Development Program, please contact Maureen Smith, Chief Development Strategist, via email or 415-472-3780.
Replies to This Discussion
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Permalink Reply by cws on
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There are only a handful of countries who have approved this drug...Australia is not one of them yet. It is a relatively new drug that just cam into existence in 2012, so there is hope for all to eventually have access.
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I don't believe so. I should preface my comments by stating that everything I am discussing pertains to the US market.
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Permalink Reply by T on
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If this is true i will be so freaking happy i have been suffering so much from this over my lifetime. I would give almost any price for something that would fully cure it!
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Permalink Reply by Cheri A on
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Incredibly exciting news. I see my specialist in a couple of weeks. I'm going to ask him what he knows about availability in Canada.
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Hi Cheri, Did you find out anything about this drug in Canada? I honestly am almost in tears thinking about finally having hair again. Thanks Don
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Permalink Reply by Leslie Mader on
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This is the best news ever!!!! Thank you Dr. Christiano for stating this disease is NOT simply an appearance-altering disease!!!
I hope that these breakthroughs with FDA approved drugs for AA lands on every dermatologists desk over the entire world!!!!!!!
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Hi Everyone
Just to add a little further information. The information around this study has not fully been disclosed. The initial study was done with 12 people (3 grew their hair back), the rest of the information is being held back (possibly for further investigation). At this time even though this is very encouraging the information is not fully worked through.
This weekend there was a meeting in the UK (Alopecia UK). It was a very well run meeting with some well educated speakers. The dermatologist at the UK meeting was also very encouraged but had felt it was very early days to be feeling this was going to be something that would work exceptionally well. There are some known side effects to this drug...the worst being Lymphoma (Cancer), also various other side effect such and hypertension. Also, the study was very small, so therefore somewhat anecdotal. The cost around the drug at this time in the UK would be 40,000 pounds per person per year.
I'm always so hopeful that the work that is currently being done will help those with alopecia...but I also know that the drugs being tested will not go to a 'so called' cosmetic condition, if it had the ability to cause worse conditions.
Stay hopeful, but investigate everything thoroughly before you take that leap.
Rosy
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I believe that the loss of a particular enzyme causes HAIR LOSS and, if one uses the enzyme on a daily basis as a shampoo it will stop ones HAIR LOSS and, resurrect the hair follicles which will start to regrow. Read on.
I discovered a cure for treating HAIR LOSS. Upon using the lotion my hair stopped falling out within one week. About 3 weeks after daily usage of the lotion I noticed fine shoots of hair growing at the sides of my bald scalp. Gradually little shoots of hair started growing across my entire bald scalp. My new hair was as soft as and, the same colour as that when I was a baby. After it had grown to about half an inch it changed to my present day colour. My hair grew long enough to be tied in a pony tail. I stopped using the lotion after 6 months and my hair continued to grow naturally. Then, two and a half years later, in 2005 I had a Liver transplant and, about 4 weeks later I noticed my new hair started to fall out. By about March 2006 half my new hair had fallen out and, by about May 2006 the rest of my new hair had fallen out. I thought it had something to do with my Hi-Tech tablets and, yes, I learned it was a particular brand of tablet (namely_PROGRAF) that I have to take for the rest of my life. However, I started using the lotion once again in August/September of 2006 and, Lo & behold, shoots of hair appeared across my entire bald scalp. Alas, for reasons unknown to myself it refused to continue its growth beyond one eighth of an inch. It has been the status quo since then.
America alone has an estimated 40 million sufferers and, there are more than 1.5 Billion sufferers world-wide. My achievement is that I have discovered the enzyme that prompts hair follicles to resurrect itself and, unlike other products ones hair will not fall out if the lotion's daily usage is stopped after about 6 months.
Would a sales scale of 1,000 Euro per customer please those suffering from alopecia?
I have an appointment with an influential body and, hope my discovery is taken forward.
However, I need about 10 alopecia sufferers to try my discovery thereby proving its efficacy. I am not making a claim in order to sell the lotion to gullible sufferers. I personally find it despicable that shysters promote a cure for alopecia to the estimated tune of 3.5 Billion US$. in the USA.
So here we go. The particular lotion had FDA OTC approval but, was discontinued because of competition from other products. During the past year on several occasions I tried another product containing the relevant "enzyme" to no avail. Then for some unknown reason about 2.5 weeks ago I tried another product with a different formulation which also contained the relevant "enzyme". It was absolutely "Fandangled Fantabulous" (an exclamation I use for excitement). My hair has started to grow again. I am also assuming that its present growth will continue. What I now have to do is get a photo of my blond hair (that which I was born with, as my hair changed colour to black in later life) and, post it as 100% proof of my claim thereby validating the efficacy of this product, though it is only proof in the case of one person. MYSELF. Assuming I have definitely cured the problem, it means I have overcome the severe side effect of my Hi-Tech tablet called "PROGRAF." So therein or is it herein lies my problem. The product has FDA OTC approval. How do I overcome the situation whereby any unscrupulous Pharmaceutical Company finds a loophole and, steals my discovery which I have yet to patent?William Rehling
26th. September 2014
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not sure if scam
otherwise you will be on that Billionaire status....
send me a pm, I will try your product
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