My doctor suggested i try it specially compounded.... I currently seem to be going from universalis to totalis... not sure what has brought about this change. I eat right, exercise a lot, and have had alopecia in my life for 40 years. I have added fish oils to my supplement regimen and my doc feels i have lessened my inflammatory levels. He said the low dose naltrexone can do this too. Thanks for your help, Rie