New treatment must be just around the corner?

With new drugs developed recently for other autoimmune diseases such as RA and psoriasis (though suppressing the immune system is dangerous in and of itself, I know) shouldn't this move them closer to an effective treatment for alopecia?

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Permalink Reply by Tony J. on February 15, 2011 at 10:50pm
Something interesting I've been reading about lately, a research study looking at ways to prevent progenitor stem cells from being destroyed. The research study is an in-vitro study done at the Kyungpook National University Hospital in Korea. Although the study was done in support MPB, from a 1999 study, a research group found "A.A. Inflammation attacks the progenitor cells but spares the follicle stem cells."

Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone- induced dickkopf-1 expression in human hair dermal papilla cells

http://www.bmbreports.org/jbmb/pdf.php?data=MTEwMjA1MDJAcGRmX3JhaW5...

Abstract
In a previous study, we recently claimed that dihydrotestoster-
one (DHT)-inducible dickkopf-1 (DKK-1) expression is one of
the key factors involved in androgen-potentiated balding. We
also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P)
represses DHT-induced DKK-1 expression in cultured dermal
papilla cells (DPCs). Here, we investigated whether or not
L-threonate could attenuate DHT-induced DKK-1 expression.
We observed via RT-PCR analysis and enzyme-linked im-
munosorbent assay that DHT-induced DKK-1 expression was
attenuated in the presence of L-threonate. We also found that
DHT-induced activation of DKK-1 promoter activity was sig-
nificantly repressed by L-threonate. Moreover, a co-culture sys-
tem featuring outer root sheath (ORS) keratinocytes and DPCs
showed that DHT inhibited the growth of ORS cells, which
was then significantly reversed by L-threonate. Collectively,
these results indicate that L-threonate inhibited DKK-1 ex-
pression in DPCs and therefore is a good treatment for the pre-
vention of androgen-driven balding. [BMB reports 2010; 43
(10): 688-692]
Permalink Reply by Laura Adams on May 9, 2011 at 1:46am
Thanks so much Tony, thats the kind of info I was after!

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