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topical ruxolitinib
hi everyone,
i can't find a specific discussion topic related to this (but i think the "search" function on this website may be faulty; even when i search for topics that i know are on here, they don't come up).
anyway, my 9 year old daughter was diagnosed with ophiasis subtype alopecia areata about 8 months ago. we tried intralesional steroid injections and monthly oral prednisone pulses. after 7 months, there was overall progression of disease. a few weeks ago, we started her on topical ruxolitinib from chemrx in philadelphia.
the pharmacist i spoke with said that some of their patients are definite responders to the drug, but on this website, i've seen comments suggesting that most patients do not respond to the topical form.
if you are doing topical ruxolitinib (or topical tofacitinib), please let us know how you are responding.
thanks,
mo
Replies to This Discussion
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Permalink Reply by mtran2000 on
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I believe there are clinical studies in progress testing topical tofacitinib. so the jury is still out on the effectiveness. My guess is topical tofacitinib will not be as effective as Xeljanz.
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Permalink Reply by mo on
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yes, and both topical tofacitinib and topical ruxolitinib are currently available from chemrx, so please comment if anyone has any experience with either. thank you.
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8 weeks topical Tofacitinib from ChemRx, no results :-(
Incyte stopped development of topical Ruxolitinib based on bad phase 2 data.
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8 weeks is pretty short to both stop the immune response and have the follicle start doing it's business again. I believe the oral jak inhibitor users have been recommended 3 months for results, and in practice some are taking a bit longer than that
Do you have any source on Incyte stopping development? In their February 2017 report they indicated that they were still working on phase 2 testing for alopecia patients
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Unfortunately, this information looks right.
https://finance.yahoo.com/news/incyte-reports-2017-first-quarter-11...
From the article:
In January, Incyte initiated a Phase 2 trial of topical ruxolitinib for the treatment of patients with atopic dermatitis, and a Phase 2 trial in patients with vitiligo is expected to begin in 2017. After 24 weeks of treatment, Incyte has determined that data from the recently-completed randomized Phase 2 trial of topical ruxolitinib in patients with alopecia areata do not justify progression of the program into pivotal studies.
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hi do u have any info for the trail of apremilast for aa?
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did you actually get a dermatologist to sign off on a prescription for the topical drug? I know people here have talked about getting things blended up, but I think you're the first using it on a child
how many people is chemrx currently providing this to? their data, while not scientific, would be interesting to see
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HI ,
I hope this medicine works for your daughter I have 16 years old boy who has Alopecia Totalies. We have tried everything possible nothing worked. Now we are looking into using Topical R along with PRP sessions.
Please keep me posted the update if TR wis working for your daughter.
I came upon this trail from this site it might be helpful for you.
Topic 'Topical ruxolitinib from Dr.King'
Thanks,
H
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we have only been using it for about a month, so we haven't seen any response yet. dr. king says to give it 3 months.
i spoke with a pharmacist at chemrx in philadelphia, who said that they do have some patients who respond to it, but she couldn't give a percentage.
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yes 3 months at a minimum for follicle to become reactivated and then start growing again.
What I've found with my son's recent episode is that once we start treating it with clobetasol it takes about 1 month before the spot stops shedding, and then 1 month before regrowth begins (this is not standard reaction with clobetasol, most people do not find it effective)
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