Comment by Mike Staffieri RHN on October 7, 2015 at 7:09pm

synopsis for the above...every auto immune disease has a microbial connection

Comment by Jason on October 11, 2015 at 11:43am

hows the progress mike? 

Comment by Mike Staffieri RHN on October 13, 2015 at 11:46am

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939833/

In the skin, however, the mTOR-dependent persistent proliferation of epithelial cells within the HF in response to Wnt1, or the direct activation of mTOR in HF stem cells, may result in the exhaustion of the HF stem cells compartment. In this scenario, excessive proliferation and activation of mTOR in stem cells may increase their turnover, prematurely exhausting the ability of these stem cells to repopulate the hair follicle. Consistent with this, pharmacological inhibition of mTOR with rapamycin was sufficient to prevent stem cell ablation upon Wnt1 expression, as reflected the maintenance of the population of CD34⁺ bulge stem cells. mTOR inhibition also impaired the acquisition of a premature senescence phenotype caused by Wnt1 expression in mice and by the exposure of CD34⁺ cells to Wnt, thus raising the possibility that mTOR may contribute to OIS when triggered by the aberrant activity of other oncogenes, an area that will warrant further investigation.

NAC is key to MTOR deactivation so the stem cells can repopulate the hair follicle

Comment by Mike Staffieri RHN on October 16, 2015 at 11:02am

http://selfhacked.com/2014/11/11/treg/

good article on increasing Treg cells

quote from the article

However, I’ve done well on NAC and most clients report positive results.

In addition, many benefits have been report in a clinical trial: NAC increased mitochondrial membrane potential in all T cells, profoundly reduced mTOR activity, enhanced apoptosis, reversed expansion of CD4−CD8− T cells, stimulated FoxP3 expression in CD4+CD25+ T cells, and reduced anti-DNA production. (R)  Increased mitochondrial membrane potential leads to destruction of activated T cells. (R)

I think what might be happening here is NAC may briefly decrease the induction of tolerance for a couple of hours.  Since it’s brief, it’s not an issue.  Otherwise, NAC may behave differently when people ingest it.  Whatever the case, I think the benefits outweigh this potential negative."

Comment by sadele on October 17, 2015 at 7:53pm

Do you know if NAC and Berberine can be take with another biologic JAK3 inhibitor? For example, Xeljanz - the same medication the guy took to treat his psoriasis and his hair grew back. I'm wondering if there is any contraindication for taking all three. 

Comment by Jason on October 17, 2015 at 9:36pm

continuing to make progress Mike? Pictures? 

Comment by Mike Staffieri RHN on October 18, 2015 at 11:12am

NAC is a glutathione precursor so it would actually recycle drugs out of the body faster so I would not suggest pairing it with Xeljanz. Picture's are coming....be patient. All I can say...it's the most hair growth on different parts of the body that I've experienced since getting AU 20 years ago

Comment by Mike Staffieri RHN on October 24, 2015 at 10:01pm

doing a bodily check for new growth...I found hair growing in an odd spot...my shoulders

Comment by Mike Staffieri RHN on November 13, 2015 at 2:51pm

hair growth so far

lower right eye lashes

upper right eyelashes

mustache on one side only thick growth

head mostly baby type hair on crown

middle chest hair with extension to belly button and some on shoulders

facial hair is sparse so far

Comment by Mike Staffieri RHN on June 9, 2016 at 8:43am

still using berberine and nac intermittently...eye lashes coming in nicely...hair on head still in places...my nails which were a big problem...splitting and cracking are very strong now. I caught this new article about vitamin D and alopecia...I got tested and I was severely low...taking 5000ui a day and I will get tested in 3 months...will keep you posted on hair growth changes

http://www.vitamindcouncil.org/blog/vitamin-d-receptor-may-play-an-...

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