Turn Xeljanz from a pill form to a topical cream

Does anyone know of a dermatologists in NY that can turn Xeljanz in the pill form to a topical cream?

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Permalink Reply by Scott on November 16, 2015 at 5:17am

I don't live in the States, but I wonder if there is the option of having the topical cream made by a compounding pharmacy. The traditional role of compounding pharmacies is to make drugs prescribed by doctors for specific patients with needs that can't be met by commercially available drugs.

Below is how Dr Christiano describes making the cream in her study. As I understand it, this is for making both a Ruxolitinib version, and a separate Tofacitinib (Xeljanz) version. I don't know if it's a complete instruction set. Presumably, only the compounding pharmacy would be able to determine that.

"Ruxolitinib was purchased from ChemieTek (catalog no. CT-INCB). Tofacitinib was purchased from AbMole BioScience (catalog no. 477600-75-2). Hedgehog agonist (SAG) was purchased from EMD Millipore (catalog no. 566660). JAK-STAT inhibitors were dissolved in DMSO and used at 2 to 3% for in vivo experiments, as indicated, and 400 nM for in vitro experiments. SAG was used at 120 μM, as described by Paladini et al. (2)."

http://advances.sciencemag.org/content/1/9/e1500973.full

Permalink Reply by Giusep on November 30, 2015 at 6:02pm
Hey Scott thank you
Permalink Reply by 3ebdie on November 30, 2015 at 8:15pm
Where are you from giusep? You are aware of the fact that there are trials ongoing at the moment in the states for topical ruxolitinib in alopecia? They are already reqruiting! Here is the link: https://clinicaltrials.gov/ct2/show/NCT02553330
Permalink Reply by Peachfuzz on December 1, 2015 at 5:19am

I'm taking part in a clinical trial in Australia next year for JAK inhibtor topical, going to be interesting to see what happens, quite exciting  really

Thanks for the posts

Permalink Reply by 3ebdie on December 1, 2015 at 6:30am

That is really nice! By whom is this trial sponsored? Incyte as well? Do you also have a link to the trial and is it a topical form of ruxolitinib as well or is it topical tofacitinib (xeljanz)? I just ask these questions out of curiosity.

On the link I posted they are only recruiting for the States. 

Permalink Reply by Peachfuzz on December 1, 2015 at 6:42am

Its by an independent clinic trialing both ruxolitinib and tofacitinib topical. It seems there is good options Stateside for trials

Permalink Reply by marisa on December 7, 2015 at 10:19pm
Does anyone know if the topical ruxolitinib would be vovered by insurance?
Permalink Reply by Robertijenkins on February 25, 2016 at 5:02pm
Can you possibly forward me the details of the trial please. Am very keen to try the JAK topical inhibitor. I agree, it's very exciting. I have read some great reports.

Thanks
Permalink Reply by Peachfuzz on February 25, 2016 at 5:14pm

If you search online you will find trials in various parts of the States, if thats where you are

Permalink Reply by Robertijenkins on February 25, 2016 at 5:56pm
Sorry, i should have mentioned that i am also in Australia. I haven't had any sucess in finding anything online.
Thanks
Permalink Reply by Peachfuzz on February 25, 2016 at 6:05pm

Where are you in Australia?

Permalink Reply by Robertijenkins on February 25, 2016 at 6:25pm
I am in Victoria, but am happy to travel anywhere. I am self employed, so taking time off isnt a problem

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