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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by James 2me on
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What was youre severity and how long were you without hair also how long before you saw growth and what was youre dose. Thanks
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Permalink Reply by Jcortez05 on
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I was progressing to AU .. Had lost almost all body hair and most eyebrows but still had almost all lashes lost just a couple. Now I have hair everywhere.
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Permalink Reply by Xeljanzmiracle on
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To read my background and see my regrowth pictures pull up my discussion called "From Totally Bald to Regrowth in One Month!" I started on 10 mg last July 28th and increased to 3 pills a day in November. Will post updated pictures soon.
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Did anybody up there dose to 3 pills a day on there own without drs consent. ? Labs are all good I'm at 9 weeks today on 2 5 mgs a day facial hair growth prominent but nothing on scalp yet also no eyebrow or lashes showing up yet I have been A U for 10 months. Thanks for all answers and comments good Luck to all. This disease is physcological at a very high Level
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James, aren't you on 10 mgs a day, not 2.5 mgs?
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Yes jcorez05 is correct I take two. 5 milligram pills a day and was thinking about adding a third dose
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Funny! I just hope she (Sadele) is ok.
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Permalink Reply by sadele on
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Hi Xeljanzmiracle! I got your email, I haven't been on here for a few weeks... life had a turn in a distracting direction and I just didn't put time into going on this website. I did see Dr. King, it was a short appointment as I had to catch a flight back to Seattle. He is happy with my progress, in fact, he seemed very pleased. He gave me some injections along the hair line to see if that will fill in. I've been shaving my head but as of that last appointment, I'm going to let it grow and see how much I actually have. I took some pictures, which I will post. I have my lases coming in and my right eyebrow is filling in. I only have about 6 hairs on my left brow. He did mention the Ruxolitinib, and possibly going that route if things stayed as is. He said it's good to have it in my "back pocket". I'm scheduled to fly out and see him on July 1st so another appointment. He mentioned that it's more of a matter of "time" instead of "dosage", (increasing). I've been taking 20mg since Septmeber 2015. I started this whole xeljanz thing in July 2015. So this July will mark 1 year. He seemed to think that I am right on track and we will really evaluate if I want to switch over to Ruxolitinib at my 1 year mark. Let me know if you have any questions!
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