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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by Gintare on
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Hello, I have alopecia universal 18year now I am 39and start xeljanz,before 4weeks have white hairs but again lose: anybody having like this?
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Hi Everyone - I've been following this discussion from the very beginning, and I've not spoken up until now. I wanted to start by thanking everyone for sharing their stories!!! For me, it means so much to find a place where there are others who are going through this too and willing to share what they are trying and the background work. I just turned 45 and was first diagnosed with AA at age 14, which was treated successfully until 39 w/kenalog injections. Then all my hair fell out in a very short time. I have seen Dr. Richard Strick (UCLA) and Dr. Arnie Klein. I tried DNCB, squaric acid, Prednisone/cyclosporine (that worked, but my hair fell out after 6 mos.) I've moved east and am finally going to see a rheumatologist tomorrow. I have years of patient-expert research under my belt and all the information that you all have been kind enough to share. I already have my Pfizer co-pay card for Xeljanz and I am covered by two health insurance companies. PLEASE, think good thoughts for me tomorrow! I'll check in!
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That's great news! can I ask which health insurance you have? Do you have a doctor out East yet?
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Hello I am french come out when try them private hospital of xeljanz and ruxolotinib will be revealed and if he(it) this year will be approved for the AA
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Okay so here is my 3 completed months difference. I wish I had better quality before pics. But here is the back of my head. I started 2/17/15 at 10mg a day. The before pic contained some bald spots, but predominantly very thin hair as it was worsening in a diffuse/patchy pattern. This is actually a big surprise as I hadn't ever seen the back of my head really. And don't mind my screwed up hairline. But, to be honest, having a bad haircut is almost a blessing right now. I definitely doubted Xeljanz the last few weeks. But just lately have I been realizing it is absolutely working. Stay patient guys, that's all there is to it. My hair has still been shedding, weirdly. So even that can be a sign of possible good results? Are the new hairs pushing out the old ones?! Who knows.
Be patient and spare yourself the fear and anxiety of it not working for you. At one point I even thought I had developed scarring alopecia... thankfully I do not. I still have a way to go (above my ears) but it will happen. I will continue to keep you guys posted.
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Permalink Reply by AlopeciaDestroyedMyLife on
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It's coming along nicely Tamer. I can see a big difference.
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