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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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Replies to This Discussion
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Permalink Reply by Patchesforlife on
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I heard that low dose Naltrexone is really good for normalizing autoimmune diseases. I found website https://www.buyldn.com that sells ldn with no preacribtion needed. I have no idea whether its a scam. Do we need a prescription for ldn? please let me know your thoughts if you had any experience with it
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I've ordered twice. First lot came through fine, the second lot I'm waiting on but I ordered right before Xmas so I'm not expecting it yet to be honest. It came via Israel, seems to work ( no miracles but I feel fine and alongside xeljanz my hair ***seems**** to be growing faster (this is only my own opinion btw could be placebo) and came with a script signed by a pharmacist saying the low dose meant nonprescription necessary. I found it through an affiliate site which was all about LDN and had a far bit of information via academic type literature on it and it was listed as one of list of trusted vendors ( others being actual doctors who prescribe it). Good luck Patches!
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I take LDN, prescribed by my funcional Dr. It has to be compounded at the pharmacy. I would be reluctant to try it if it didn't come from a pharmacy that knows how to compound it. Find a functional physician, they will be more helpful with this prescription. It's fairly inexpensive, 129.00 for 90 day supply.
I thought it was working great and then my hair fell out again. Maybe too much sugar during the holidays. It can't hurt to take it.
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thank you Carlie. Its sad that you lost it :(. I was hoping it might help. Did you stop taking it and then it fell? did u havr complete growth at that time?
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It seemed to come in quickly to about 1/4 of an inch fine hairs all over my
head before lost it all. I'm still taking the LDN but I stopped the minoxidil. I will continue the LDN and hopefully it will eventually work. I'm AU.
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thank you so much Frida!
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I don't see why not. LDN is not harmful at all. It's actually like taking a supplement.
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When xeljanz is working by suppressing the immune system,LDN is trying to treat it by strengthening it.I think that this can cause both of them to have low effectiveness when used together.
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is LDN strength ening the immune system? that shouldnt be good right? we dont want our immune system to be atronger
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Everywhere I read it says that LDN strengthens the immune system and normalizes it. It is used as a adjunct treatment option in cancer and MS disease.But it says it can be used in autoimmune diseases.
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now im afraid to take it
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