Alopecia World
www.alopeciaworld.com
Am lost.. an article for discovering the cause for alopecia areata - alopecia universalis
A Mouse Model of Clonal CD8+ T Lymphocyte-Mediated Alopecia Areata Progressing to Alopecia Universalis
Rajshekhar Alli*, Phuong Nguyen*, Kelli Boyd*,†, John P. Sundberg‡ and Terrence L. Geiger*
+ Author Affiliations
*Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105;
†Department of Pathology, Vanderbilt University, Nashville, TN 37232; and
‡The Jackson Laboratory, Bar Harbor, ME 04609
Address correspondence and reprint requests to Dr. Terrence L. Geiger, Department of Pathology, St. Jude Children’s Research Hospital, 262 St. Jude Place, D-4047, Memphis, TN 38105. E-mail address: terrence.geiger@stjude.org
Abstract
Alopecia areata is among the most prevalent autoimmune diseases, yet compared with other autoimmune conditions, it is not well studied. This in part results from limitations in the C3H/HeJ mouse and DEBR rat model systems most commonly used to study the disease, which display a low frequency and late onset. We describe a novel high-incidence model for spontaneous alopecia areata. The 1MOG244 T cell expresses dual TCRA chains, one of which, when combined with the single TCRB present, promotes the development of CD8+ T cells with specificity for hair follicles. Retroviral transgenic mice expressing this TCR develop spontaneous alopecia areata at nearly 100% incidence. Disease initially follows a reticular pattern, with regionally cyclic episodes of hair loss and regrowth, and ultimately progresses to alopecia universalis. Alopecia development is associated with CD8+ T cell activation, migration into the intrafollicular region, and hair follicle destruction. The disease may be adoptively transferred with T lymphocytes and is class I and not class II MHC-dependent. Pathologic T cells primarily express IFNG and IL-17 early in disease, with dramatic increases in cytokine production and recruitment of IL-4 and IL-10 production with disease progression. Inhibition of individual cytokines did not significantly alter disease incidence, potentially indicating redundancy in cytokine responses. These results therefore characterize a new high-incidence model for alopecia areata in C57BL/6J mice, the first to our knowledge to apply a monoclonal TCR, and indicate that class I MHC-restricted CD8+ T lymphocytes can independently mediate the pathologic response.
Footnotes
This work was supported by National Institutes of Health Grants R01 AI056153 (to T.L.G.) and R01 AR056635 (to J.P.S.), the American Lebanese Syrian Associated Charities/St. Jude Children’s Research Hospital (to R.A., P.N., K.B., and T.L.G.), and the North American Hair Research Society (to K.B.).
The online version of this article contains supplemental material.
Received March 8, 2011.
Accepted October 22, 2011.
Copyright © 2011 by The American Association of Immunologists This is the all text and i copy and past it all as it was now i don't really get the text because all the scientific words, what does retroviral transgenic mice even mean?? Does it mean a mice that had retrovirus and that passed it to the other mice?Sadly i think they mean that, am not sure did look up some retroviruses if this is the case they are contagious and remain in body for life cause all kind of problems and even breast cancer that i didn't even know was a cause from virus and leukemia to now seems for alopecia as well..
-
Comment by Disaster on January 28, 2012 at 3:58pm
-
Damn why they just cant say it is this and that yes contagious not and how may be spread the text is even confusing me hope someone smarted can post and help us both.Same get it as you that an infected mice infected a rat awesome was hoping was not so bad retroviruses are not curable..
-
-
Btw a retrovirus fits the picture because i found on the internet a man getting alopecia universalis in the 1890 so means is not a new disease that was something from way back
-
Comment by Julija on January 28, 2012 at 4:07pm
-
Yes i also find on the internet just now that retroviruses show no signs even for 9 years and when does is rash or cold like i have both and now am even more scared:(
-
Comment by Tallgirl on January 28, 2012 at 6:54pm
-
Speaking of genes, I just learned in the latest issue of MORE magazine that whoever discovers a gene can patent it and charge thousands of dollars to those wanting remedies that should cost far less. They want the researchers to get paid somehow. A female lawyer is working on such cases and was profiled in the magazine. So...the implication is that if genes are found related to alopecia while someone is working on another condition, the info may NOT be as accessible as we would hope. This may go to the Supreme Court, because decisions keep getting repealed and challenged.
-
-
Awesome to patent it as if was a face cream discovery genes are found for alopecia but with the mix with retrovirus so am sort of lost if they are saying is a virus because they mention a retroviral thing i found the total research on other site julija you posted the one from the short version other web has 2 but thank you so much for the info maybe i should post the all version but short told alopecian mice got a surgery where they took skin and add it try surgery on un alopecian mice as hair transplant the mice went afected..Now this freaks me out even more means is contagious i was always thinking it is but was hoped am wrong
-
-
un alopecian mice = healty mice to not have confusion but yes this is like shock means this if i got it right and they are saying is retrovirus at least could say what type truth is retroviruses as sneaky they dont show nothing is wrong with you with years means ppl that have alopecia could transmit it to there partner retroviruses cause the cells to act not normal because they change there dna simple example is aids it causes the cell to die by adding his own to it there was actualy a case of aids that caused alopecia universalis so all i can say is damn,have tested my self for this luckely dont have it also tested my self for a lot or other things that turned out dont have it but i didnt test my self for all retroviruses that are contagious to ppl honestly i started to think hmm maybe are genes because all doctors told me i am not contagious i do research alopecia for 6 years but was like they must be right they are doctors, am not i tested all but thous things and got a gf am dating for month now and now am in panic i could have pass her something like that....dammmmmmmmmn am just really sad mad i didnt listen to my self and started dating.Sorry for some text eror am just really upset after reading the all and proven research they should never claim is not contagious if they arent sure
-
-
Can imagine how you feel disaster am freaked out to the bone my self, so what now we should test all retrovirus? i don't even know how much are there am so tired of it all really tired i have so much problems and all i needed was a disease now
-
-
Me to i don't know how much are there from the retrovirus type..My blood presur went 350 after the info shall try to calm..All that like to add me feel free
-
Comment by Karen Smith on January 28, 2012 at 8:48pm
-
I don't think this article means the disease is contagious. I am sure I would have caught it from my daughter by now. It is difficult to understand, I will ask my med student son to interpret it next time I see him. I am glad that someone this smart is working on a cure. Take one day at a time and try not to worry about what will happen next. It drives you crazy!!! I know this from experience.
-
Comment by LilyBell*Murphy'sLawLuvsMe on January 29, 2012 at 12:33am
-
If it were contagious we would see widespead cases of it within famalies - which we do not. There are a few isloated cases but that is conincidence. please stop worrying. There are even identical twins with only one developing alopecia and they have the same dna.
© 2024 Created by Alopecia World.
Powered by
You need to be a member of Alopecia World to add comments!
Join Alopecia World