Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol

https://www.frontiersin.org/articles/10.3389/fimmu.2021.655739/full...

It has later been shown that resistance to 1,25(OH)2D3 in such children is frequently caused by hereditary VDR defects, resulting in hypocalcemia, secondary hyperparathyroidism, rickets and in about one half of the patients' alopecia (25–27)

I personally have a SNP on my VDR gene that hinders conversion of sunlight into vitamin D  and I have light skin to boot. I got my vitamin D checked two years ago, and it was dangerously low

I currently take 10000 UI a day for the last 2 years...currently at 250 nmol/l.

Before my alopecia, my nails were a sign something was wrong

Observations...I do not have any before and after photos.... but my nails for years were ghastly to look, cracked, spoon shaped and red nail beds....now after taking Vitamin D in high doses, they are beautiful strong and pink once again

As for the hair...I'm 57 now so I see some new hair but it's mostly white and sparse


what took years to develop into alopecia is not going to turn overnight unless I take rheumatoid arthritis drugs (they work in reversing AU BTW...see previous posts)

I will stay the course on vitamin D as it offers protection from viruses as well. There is also a microbiome component to autoimmune disease...pathogens like Clostridium can cause havoc...I had some of that in high quantities too and got rid of it.

Will keep you posted

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Comment by Pat on October 13, 2021 at 6:50pm

Hi Mike, that is a very interesting article - difficult to translate but I got the gist. My Vitamin D has always been good, but according to this article that isn't a particularly good indication I have enough to counteract the PTH as stated by the article -  "A hallmark of acquired vitamin D resistance, if it exists, would be an elevated parathyroid hormone (PTH) concentration despite 25(OH)D3 levels being in the ideal range and thus indicating sufficient production of 1,25(OH)2D3."

Were you able to have your PTH checked to see whether it was true in your case?

I'd be interested to see if you have had any more results since this post. 

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