Alopecia World
www.alopeciaworld.com
Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
-----------------------------
AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
-
Permalink Reply by William on
-
Hello HS, have you considered upping the dosage for a while until your alopecia is stablized? Thanks
-
-
Sorry to write here but i can not open a new discussion ...have you news about baricitnib-lilly? whe will be possible buy it? in the trials appears whit no important sides effects...or i understood bad???
i'm in almost 2 months of xelijanz and i'm afraid for the sides effect post a man in this forum i thought it was sure
https://www.google.com.ec/?gfe_rd=cr&ei=14xDV9HEHsnT8gezpYzoBw#...
-
-
I'm also interested in the drug baricitinib, but I do not know if it was already approved, I am using xeljanz 2 pills a day with little result
-
-
Lu391 or other do you know like make xelijanz in cream? or like they made baricitinib in cream(i read they made a trial whit baricitinib cream and it worked super)...
-
-
How long have you been takeing Xelljanz and how severe was you're case and how long did you have hairloss. Also Barcotinib is not approved yet I think it's 6 months away. And is no big difference from xelljanz
-
-
I think baricitinib is Jak 1/2 where Tofacitinib is jak 1/3 so it signals a different pathway. I have heard of people switching to ruxolitinib if they never had response to tofacitinib. The reason why Is because it is also jak1/2. So people could benefit from baricitinib as it's likely to be cheaper than both and is jak1/2.
However some say it's proven to be safer but I know Susan asked Dr King about baricitinib and he said he would not reccomend or give Baricitinib to any of his patients..
-
-
The Ruxubarin is expensive and dangerous it is used to treat mylofibrosis which is a form of bone cancer marrow. I think I would choose no hair over that drug also I think it's 8.000 $ a month and that's what you will pay beings no insurance company is paying for it to treat hairloss
-
-
Yeh James it's personal choice for those who are not responding on tofacitibib and for that reason and the price makes it not affordable however baricitinib night be affordable of people need to go down the jak1/2 route. However I still don't know how much Baricitinib will likely be.
The price on these jak inhabitor are ridiculous.
But as most of us are using this as a bridge to hopefully one day have a safe cure or safe treatment.
-
-
P.s was talking about the Baricitinib apparently being safer so the studies showed.
-
-
not only safer a lo ot safer approxly noone side effect cause it attack jack 1 and 2 no jack 3
-
-
Why would not reccomend if in the trial whit alopecia the results are very good and it is safer???
i read this post and i can not understand if Dottor King is saying us the true about xelijanz side effects or not
Reply by Jen
Look at the data on the phase three studies. These are the first part of the safety profile graphs. I linked to above. All you have to look at is where the placebo is and where Xeljanz is to see the effect of the drug. And remember these were just short term studies. I would love to hear what Dr. King says to his patients about the safety profile. He seems like a very nice person. Maybe someone who has seen him personally can comment on his analysis of the risks.
In the meantime, here is a disturbing article about how stock analysts who invest in Pfizer see Xeljanz as unsafe: "The problem arose with some Wall Street analysts questioning Xeljanz's safety profile and wondering whether it was really a step up over Amgen's Enbrel and other plaque psoriasis medications already on pharmacy shelves. Though all approved medicines have possible side effects, Xeljanz's list of potential adverse effects is quite long. I suspect what really concerned Wall Street, and perhaps the FDA, was that Xeljanz can lead to an increased risk of developing skin cancer and lymphoma."
http://www.fool.com/investing/general/2015/12/22/pfizer-incs-bigges...
They can't get it approved for plaque psoriasis and they are looking for another market for it, they are happy to take Alopecia money in the meantime. They are selling a half billion dollars of it annually.
© 2024 Created by Alopecia World.
Powered by
