Xeljanz (Tofacitinib Citrate): My experience on the trial

I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.

I thought it would be nice for everyone if I documented my progress on here. 

Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.

The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results. 

I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.

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AW:  Other discussions on Xeljanz / Tofacitinib

https://alopeciaworld.com/main/search/search?q=Tofacitinib

 

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Permalink Reply by Ahmed on August 10, 2016 at 6:08am
Hello Ertan,
From what I understand, Xeljanz is not a cure, it's a treatment that you have to keep taking in order to grow hair and maintain your hair regrowth, just like Minoxidil for bald men. Most people who stop taking Xeljanz experience hair loss again.
Permalink Reply by Peachfuzz on August 10, 2016 at 6:16am

Have you had a good response to the Xeljanz over that time?

Permalink Reply by ertan on August 10, 2016 at 7:52am

Yes i have , approximately 15 cm 

Permalink Reply by Peachfuzz on August 10, 2016 at 6:18pm

Full regrowth of scalp, eyebrows and lashes?

Permalink Reply by James 2me on August 10, 2016 at 7:38pm
What was you're severity peach fuzz ? How much hairloss how long was you're hairloss. And how long did it take to come back from starting Xelljanz. Thanks
Permalink Reply by Peachfuzz on August 10, 2016 at 8:12pm

Lost nearly everything 7 years ago and little or no re growth since then. I went on a clinical trial earlier this year using topical Jak inhibitors but had no response

I haven't started on oral Xeljanz yet, but I am preparing to go to Turkey to but one years supply and start asap. I ask  many questions of people to help make the correct decision

I was wondering if Xeljanz has a shelf life, does it keep it's potency for one year?

Permalink Reply by James 2me on August 10, 2016 at 8:37pm
My guess would be yes beings the containers are sealed up really well. But you can call Pfizer to reassure the shelf life. Good luck. Keep in Mind patience is key while Takeing it orally. Everyone responds different some have quick response some take longer I havnt heard to much positive info on the topical good luck keep us posted.
Permalink Reply by Peachfuzz on August 10, 2016 at 9:17pm

Thanks.

No, the topical has had few good results that I am aware of, the oral Xeljanz however, sounds like many people have had good outcomes from the oral treatments.

And yes, once I start I will be very patient as it seems some people get responses faster than others. I'm am still concerned about potential side effect though.....but it seems like few people are getting any side effects, on the short term anyway.

I am hoping that the Jak inhibitors specifically designed for alopecia and in clinical trial now, CTP-543 will have the results out this time next year, if positive and cost efficient, I would imagine many would consider a switch from Xeljanz..........

Permalink Reply by bibby on August 10, 2016 at 9:19pm
I too am preparing to visit turkey on a 1 day trip. I'll be buying 6 months supply. Just awaiting a derms advise in Ireland but reckon my minds made up regardless. Do you have up to date prices in turkey per box?
Permalink Reply by Peachfuzz on August 10, 2016 at 10:09pm

I don't have a price per box no, someone posted 1770 Turkish Lira a while back which is about $US600

Permalink Reply by Ahmed on August 11, 2016 at 1:16am
Yes you are right Peachfuzz. I recently got Xeljanz from Turkey and it costs about $600 per box. And each box contains 56 tablets.
Permalink Reply by Xeljanzmiracle on August 11, 2016 at 12:44pm
So Ahmed, when did u go to Turkey?

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