Alopecia World
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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by Starshine on
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Did you see a significant increase in growth when you started on three? I am debating on upping the dose, but of course, that will also increase the cost as it will not last as long.
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Permalink Reply by AlopeciaDestroyedMyLife on
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Not a significant increase but it did help.
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Wow! No doubt the Xeljanz is working. Time is everything as you have stated. Keep it up!
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Thanks , I'm aiming to have everything back by aug/sept but we'l see :)
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Permalink Reply by Scott on
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Thanks for keeping us up-to-date ADML. Things are indeed progressing well.
Your eyebrows seem well-developed from the overhead shot provided. Did you have noticeable eyebrows prior to taking the medication ?
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Not much eyebrow hair at all when I started. Most of it had fallen out.
I have about 85% of my brows back and new black hairs are liberally forming in the gap.
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THIS IS FANTASTIC!!!! Congrats ADML.... I need to make a suggestion though. It's time to change your name...you're getting your life back now...hence it's not destroyed. Any suggestions people???? Maybe hopeSPRIGSeternal.... HAIRwego.... ???? :)
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Not yet , but if I were to get all of my hair I would have my life back and that certainly would warrant a name change !
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It looks like you're on your way! The visible hair line is awesome...just seems like 'Destroyed' is such a harsh word. I've been AU for 4 years (second week of Xeljanz)...this disease has definitely put a damper on my life, but I'm not in pain (physically). I wish you all the best ADML. (Kat, good one!!)
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Permalink Reply by Danny on
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Have to agree with the name change, it's a bit melodramatic - Alopecia simply does not have the power to destroy a life.
I went AU at 16 so I know where you're coming from, it's not easy. But show some positivity man! If not for your own mental health, do it for the younger people on this board who need someone to look up to and see that it's not the end of the world to lack some protein filament on your head... that's pretty much what it comes down to.
I challenge you to reclaim your life while you are still in this state, because there is no guarantee any of us will be here tomorrow - hair or no hair. So why wait?
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