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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by bibby on
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Yeah , I used dermatch when I had AA (now TT). I found it fantastic. It seemed to multiply what hair I had and it blended my existing hair to the fine hair on the regrowth hair perfectly. As a result the wind never represented a problem with both the hair exposing the patches nor blowing the Dermatch off the hair. It is a different substance compared the toppik or caboki shake hair fibers and is more of a paste which is why I think it would be a great finisher to your present condition. Cheap as well on the likes of Ebay etc
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Update:
Month 5 on Xeljanz vs. month 6 on Xeljanz.
Meeting Dr. King tomorrow! - Attachments:
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That awesome Katrina
How many pills you take ?? And did you add any supplements!??
Tahnk you
sultan
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Wow Karina fantastic! At what month did you start seeing visible growth ? At which month did xeljanz kick in ?
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Amazing!!!
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Perfect
I started mine last Thursday night lets see whats is going to happen. no beard ,no hair ,no eyebrows no eyelashes.Btw people here dont mind how you look to other people or to your self (i know its kind a hard for woman ) but if it comes with stress it goes without stress thats my opinion :)
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Permalink Reply by Xeljanzmiracle on
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Youknow, stress is a factor, but this is an AUTO IMMUNE DISEASE. Our bodies are attacking themselves and harming our healthy hair follicles. Our hair growth is suppressed as a result. When the trigger is turned off by Xeljanz, our hair returns. That's the simplified answer, lol! Congratulations on your start You know. I wish u the best.
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Permalink Reply by Jcortez05 on
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I was on xeljanz and had a very stressful situation and then a month later my shedding happened lots of it to the point where I shaved my head so idk why the xeljanz didn't help in stopping it if it was turning that off
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I don't know either Jcortez, lol! This disease is peculiar and we all have different stressors, genetics, backgrounds, etc. Some people don't respond to Xeljanz at all so far. I will tell u this though. We have experienced PHENOMENAL sucess compared to others that preceded us. We have hair where there was absolutely none for many years. In my case 6 years. I treasure and am grateful for every single hair. We are truly blessed. My hair is long enough to braid and have extensions now!
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I saw light fuzz in the back of my head at 2 months in. This was when I was on 2 pills a day. I did not see a significant amount of pigmented hairs until 4 months in, when I was alternating 3/4 pills a day (which I am still currently doing).
I do several other things: minoxidil 5% twice a day, hair skin and nails supplements twice a day, Nioxin shampoo and conditioner daily, Theradome laser helmet four times a week, hanging upside down three times a week, I just started doing weekly allergy shots about a month ago (because I think my alopecia was allergy-induced), and I also just got my first round of cortisone shots about two weeks ago... I feel like the cortisone helped me so I'd like to go back for more soon.
Still no significant lash or brow growth... but they were the last thing I lost, so maybe it is re-growing in the same order?
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That's interesting. I'm seeing my eyelashes go from blonde to black. That hasn't happened in a year or two since I lost them.
I do believe the cortisone shots work. The only reason I started xeljanz was because the circular bald spots I have been treating for years became so frequent that It was time to up the treatment. I'm confident with the shots and Xeljanz I can get this under control.
Are you shedding still on Xeljanz?
I've noticed my shedding has increased. (I'm also under a lot of stress...buying, selling and moving house).
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My lashes and eyebrows were the very last thing to begin re-growing - it took almost a year to see substantial eyelash growth. Goodluck!
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