Alopecia World
www.alopeciaworld.com
Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
-----------------------------
AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
-
Permalink Reply by okan94 on
-
I started using Xeljanz twice a day.When do I start to see the effects of healing ?
-
-
what happen to interleukin study? thank you
-
-
He got some regrowth but very slow and very far from complete.
Results are not official cause it's double blinded. Soon I guess we will see official results.
-
-
so i guess xeljanz is better for now atleast.
-
-
For now yes and don't forget physician in North America hate IL2. It has a bad reputation here. High dose of Il2 can be very very dangerous.
We can only wait for the results to compare vs placebo
-
-
thank you for always answering me. Inhave one more question. If alopecia culprit cause is inflammation does that mean people with AU have constant inflammation? it seems more like genetic thing to me than a disease at least for AU. For AA i can understand its inflammation but for AU is it still inflammation?
-
-
In theory yes people with alopecia have inflammation. But reality is more complicated.
How do u measure inflammation in this case? A blood marker? Like c-reactive protein for example. Well not all alopecians are above average...
But in all recent clinical trials they did there were a strong link between patients having high inflammation markers and patients who responded very well to treatment. Even for long term of AU...
Your question is a good one but a challenging one. One could also say genetic causes you to have inflammation in a particular spot.
Look... 92% of identical twins do have same diseases even after their 40s. This means what? Diet, nutrition and lifestyle are all very important but the genes you have are number 1.
-
-
thanks!
-
-
-
Thought I'd share this- I had an appointment with my Derm on Tuesday and she told me to start taking Allegra 180mg twice daily as there has been a recent study that showed Allegra helps Xeljanz to be more effective. Has anyone else heard of this or tried this? She didn't tell me what study, or why it helps.
-
-
hi katrina. i wrote the same comment a few days ago you can find it before... my derm told me allegra helps apparently its a new study in Japan
© 2024 Created by Alopecia World.
Powered by
