Xeljanz (Tofacitinib Citrate): My experience on the trial

I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.

I thought it would be nice for everyone if I documented my progress on here. 

Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.

The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results. 

I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.

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AW:  Other discussions on Xeljanz / Tofacitinib

https://alopeciaworld.com/main/search/search?q=Tofacitinib

 

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Permalink Reply by Return_life on March 12, 2018 at 12:18am

I initially tried xeljanz for 7 months with the regular 10-15 mg per day... after 7 months multiples doctors ( not random Dr, am talking about Dr with huge reputation in the alopecia community) told me I was a non responder. 

3 months later I decided to do this my own way. Induction dose, increasing dosage regimen etc... I became a responder. 

I have been on ruxo recently... maybe 3 months now. So far very satisfied with the results but it is more expensive. Both drugs work in a similar way I would say generally speaking.

Permalink Reply by kevin on March 10, 2018 at 4:28pm

Salut return life je suis sur xeljanz depuis le 15 fevrfév c'est impressionnant j'ai des repousses des cheveux barbe sourcils. Je suis à 10mg jours. Mon docteurs ma fourni une lettre pour la douane donc plus de problème au retour en France. Je sais pas comment c'est la combinaison de linterleukine qui fait que cela va super vite. 

Permalink Reply by bibby on March 13, 2018 at 10:46pm

bonjour Kevin
Quel est le prix actuel à Istanbul pour une bouteille de xeljanz ?

Permalink Reply by kevin on March 10, 2018 at 4:33pm

60mg c'est vraiment énorme ? N'est-ce pas dangereux. Moi si cela stagne je vais passer à 15 ou 20mg . 

Permalink Reply by Return_life on March 10, 2018 at 5:49pm

Exact c est bcp mais en meme temps ca a ete necessaire. Pas oblige de rester toujours a 60mg... j ai rebaisser.

Avec il2 ton systeme etait deja aux aguets. Je suis certain que tu as bien fais de commencer xeljanz. Tiens nous au courant

Permalink Reply by kevin on March 10, 2018 at 6:27pm

À 60mg tu n'a pas d'effet secondaire ? J'ai un travail de sang chaque mois je pense retourner à Istanbul en avril ramené 6 boîte et passer à 15mg ou 20mg pendant 3 mois. Mais je trouve que seulement à ma première boîte fini cela a vite réagit j'espère que cela va continué à poussé. Tu en penses quoi ?

Permalink Reply by Return_life on March 10, 2018 at 9:36pm

Continues avec la plus basse dose tant que tu as de la repousse... C est un long processus parfois mais il vaut mieux avoir une vision long terme. 

J ai augmenter la dose graduellement... le seul effet secondaire que j ai eu c est de l acne assez severe. Mais c est parti en diminuant la dose et avec une creme.

Vas y avec xeljanz je suis certain que tu vas continuer a avoir une progression.  Je t assure pour moi c est une benediction. Ca m a redonner ma vie apres 11 ans

Permalink Reply by Anna on March 12, 2018 at 9:07am

Quel creme pour acne as-tu utilise?

Permalink Reply by Return_life on March 12, 2018 at 6:36pm

Tactupump

C est assez cher mais t en Mets tres peu. Ca brule et ca seche un max. Mais c est tres efficace

Permalink Reply by Ithastogetbetter on March 10, 2018 at 2:30pm

Hey Everyone!

I'm not sure if this post is still active but I am also trying the JAK inhibitors oral medicines, the exact same bottle in the picture. If there is anyone else out there on this trial, please hit me up! It would be great to track the progress.

Permalink Reply by Carlie on March 10, 2018 at 2:34pm

There's hundreds of posts.

Permalink Reply by Ithastogetbetter on March 10, 2018 at 2:38pm

For some reason, I was only able to see posts from 2013.

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