Alopecia Areata Universalis Precipitated by SARS-CoV-2 Vaccine

"Knowledge about SARS-CoV-2 vaccine safety and benefits is evolving to support decision-making about use of these vaccines. Although benefits of these vaccines greatly overweight risks associated with acquisition of infection, the benefit-risk balance should be communicated to patients."

A Case Report and Narrative Review

Introduction:

Hair loss is a common presentation in primary care. Among various causes of hair loss, alopecia areata (AA) represents 18.2% of the causes [1] and has a lifetime risk of approximately 2% [2,3]. AA is a patchy nonscarring alopecia with underlying autoimmunity against hair follicles with resultant dystrophy of the hair follicle at the anagen phase of growth [3,4]. Severe forms of AA include alopecia totalis (all scalp hair) and universalis (entire body). Despite multiple underlying pathophysiological mechanisms, there are two well-established primary explanations. The immune dysregulation with loss of immune privilege of hair follicles and genetic predisposition [3,5]. Other factors include infections, drugs, and vaccines with consequent immune dysregulation and development of AA.

Wise, Kiminyo, and Salive's 1997 study was among the earliest reports of hair loss after routine immunizations in their case series [6]. It is suggested that vaccines via antigen presentation, cytokine production, epitope spreading, polyclonal activation of B cells, and other mechanisms of anti-infectious immune response and autoreactivity potentially trigger autoimmunity [7]. Regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, there is a theoretical risk of inducing autoimmunity and a number of reports of different autoimmune sequela [8]; however, most frequently used messenger ribonucleic acid (mRNA) vaccines have excluded patients with a history of autoimmune conditions from their clinical trials. The US Food and Drug Administration has raised the concern of possible precipitation of rheumatoid arthritis after SARS-CoV-2 vaccination [9]. Pfizer vaccine developers have included a list of rare complications, including myocarditis and skin reactions, in the information leaflet, but AA was not listed.

In addition to the morbidity burden of AA, it is distressing to affected patients and is associated with major psychosocial sequelae and reduced quality of life [10]. This report presents a patient with alopecia universalis recurrence precipitated by the SARS-CoV-2 vaccine.

Conclusions:

Knowledge about SARS-CoV-2 vaccine safety and benefits is evolving to support decision-making about use of these vaccines. Although benefits of these vaccines greatly overweight risks associated with acquisition of infection, the benefit-risk balance should be communicated to patients. There is currently a lack of clear-cut recommendations about screening for autoimmunity in patients receiving SARS-CoV-2 vaccines and autoimmunity in this context is multifactorial with multiple modifiers. Due to the growing reports of autoimmunity flares including AA, healthcare providers should remember to enquire about personal and/or family history of autoimmunity. This would allow for proper patient-centered counselling and enable patients to take informed health decisions in their best interest.

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Comment by dreamscometrue on September 11, 2022 at 6:42pm

Reading this somewhat makes me think that early childhood immunizations is what may have triggered my AA which culminated into AU from 23 yr old to the present 59 yrs old. I've always felt that way.  No one else in my family has AA of any type, just me.  But all my siblings do have some type of autoimmune disease; eczema and asthma.  Im positive the correlation bwtn vaccines and autoimmune disorders is due to vaccines.  Although now this article seems to take a stand as to informed consent, its too little too late as there are those who have been severely effected with adverse events, permanently disabled with no answers to how it was caused, and those who have died within days of vaccination.  I dont think their defense will stand in a court of law for crimes against humanity and ill-informed consent.  Unless a patient gets a complete list of potential side affects before immunization, its not full informed consent its considered an experiment.  

2.5 yrs later, many unvaccinated people are still here and thriving.  Those who did get the virus with no treatment, still here and thriving as those who are 2x vaccinated.  I weigh the pros and cons to decide for myself if its worth the risk.  But something is amiss for AA and vaccines, that Im sure of.  AA didnt just come out of nowhere, unless it came from somewhere. 

Comment by Matt1 on September 11, 2022 at 6:53pm

Dreams come true you absolutely on the right path. 

Comment by outforawalk on September 11, 2022 at 8:07pm

I had the Covid Vaccines with no adverse reactions.   I already had alopecia before them.

Comment by dreamscometrue on September 11, 2022 at 8:12pm

@Matt1 I recently was cleaning and organizing my parents home and came across vaccination cards for me and my siblings. It's truly undeliverable what has been allowed to be injected into our bodies as kids!! Dis-ease definitely comes from somewheres and something is the thing that triggered it.

Comment by Matt1 on September 11, 2022 at 9:15pm

I ask anyone this question, find someone/ institution that has isolated covid 19, this is the first step in making a vaccine. 

Comment by dreamscometrue on September 11, 2022 at 9:27pm

@Matt1 as far as I've heard, no one has found it. That picture of the virus floating around is just that, a picture. I believe the actual 'virus' along with nano particles driven by graphene oxide are in those vaccines. Now they're talking me vaccines with no benefit of clinical trials, just straight to market. Sheep will go for it. Previous jabs untested for longevity, so who knows what will happen in the next few years. But rumor says there's new epidemic of SADS happening, starting in Asia already.

Comment by dreamscometrue on September 11, 2022 at 10:08pm

I have no one in my lineage according to my 80-90 her old parents who have developed AA. No one in my family has it but me. There are cases where people have developed AA after this recent cv19 vaccine. No one, can say anyone, is predisposed to AA, since it is believed to be autoimmune. Autoimmune is the excuse they give, when they don't know or claim to not know, where a disease comes from. It's pretty ignorant to think that vaccines are a live saver without seeing that those same vaccines have caused MANY you permanent disabilities and adverse reactions. The point is to find a common denominator to causation. Vaccines have also been known to create mutations and cause shedding of viral particles. To me when it comes to vaccines it's a matter of fully informed consent, know what you're putting in your body, and decide. If it ain't broke, don't fix it, you may make it worse than it was.

Comment by dreamscometrue on September 11, 2022 at 10:46pm

In some cases is NOT good enough, because, if the science is SO accurate, it would be definitive.  Science is theory and speculation, and only science fact when the process repeated over and over doesnt change, even when environments, additions thrown in does.  2+2 doesn't change, unless you change a variable, then its different.  I dont know all my ancestry no more than you think you know all of yours, but, I believe my parents know my family lineage better than you do, so there's that.  Its about research, and your research and mine clearly doesnt line up.  I dont jab myself out of fear.  Im still here, non jabbed, with AU, asthma and all.  I can wear eyelashes using glue. Never had problems with that.  In fact, I grow a hair or 2 on my lash line and even a few on my head from time to time.  And I do agree, I wont risk my life for growing hair.  Not worth it to me.  But I also wont risk my life for untested vaccine with ill-informed consent because Im told a virus is so deadly and contagious it took me 2 years to get a case of it.  Not to mention the CDC just recently relaxed its guidelines basically admitting they messed and said there is no difference between jabbed and unjabbed people, so there's that science. LOL. If you'e been involved in that many studies for that long, and still come up with nothing all you wasted was time.  You can throw around your credentials, I really dont care it means nothing because, here is a fact; you and I are here with the same disorder and loss of hair.  And nothing changed. 

Comment by Hope4Hair on September 12, 2022 at 1:00am

There are rare, documented cases of Alopecia universalis following COVID-19 illness. It's not surprising that there are people who experience it after the vaccine. Essentially, a vaccine is just a noninfectious, safer (hopefully) exposure to the pathogen in question. The "cytokine storm" that has proved fatal for so many patients with COVID-19 is underrecognized in medicine. I'm hoping that the silver lining to COVID-19 is increased recognition of the relevance of cytokines and the inflammatory response, in general. Solving that puzzle will, inevitably, lead to answers and permanent solutions for our Alopecia community

Comment by dreamscometrue on September 12, 2022 at 2:30am

Vaccines are supposed to contain an attenuated part of a virus, to get the immune system to build up a defense to it. The cv19 vaccine has a spike protein in it that gets in your DNA and makes your body replicate that protein in your body. Continuously. Not all vaccines are created equally. 

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