Knowledge about SARS-CoV-2 vaccine safety and benefits is evolving to support decision-making about use of these vaccines. Although benefits of these vaccines greatly overweight risks associated with acquisition of infection, the benefit-risk balance should be communicated to patients. There is currently a lack of clear-cut recommendations about screening for autoimmunity in patients receiving SARS-CoV-2 vaccines and autoimmunity in this context is multifactorial with multiple modifiers. Due to the growing reports of autoimmunity flares including AA, healthcare providers should remember to enquire about personal and/or family history of autoimmunity. This would allow for proper patient-centered counselling and enable patients to take informed health decisions in their best interest.
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Alopecia Areata Universalis Precipitated by SARS-CoV-2 Vaccine
"Knowledge about SARS-CoV-2 vaccine safety and benefits is evolving to support decision-making about use of these vaccines. Although benefits of these vaccines greatly overweight risks associated with acquisition of infection, the benefit-risk balance should be communicated to patients."
A Case Report and Narrative Review
Introduction:
Hair loss is a common presentation in primary care. Among various causes of hair loss, alopecia areata (AA) represents 18.2% of the causes [1] and has a lifetime risk of approximately 2% [2,3]. AA is a patchy nonscarring alopecia with underlying autoimmunity against hair follicles with resultant dystrophy of the hair follicle at the anagen phase of growth [3,4]. Severe forms of AA include alopecia totalis (all scalp hair) and universalis (entire body). Despite multiple underlying pathophysiological mechanisms, there are two well-established primary explanations. The immune dysregulation with loss of immune privilege of hair follicles and genetic predisposition [3,5]. Other factors include infections, drugs, and vaccines with consequent immune dysregulation and development of AA.
Wise, Kiminyo, and Salive's 1997 study was among the earliest reports of hair loss after routine immunizations in their case series [6]. It is suggested that vaccines via antigen presentation, cytokine production, epitope spreading, polyclonal activation of B cells, and other mechanisms of anti-infectious immune response and autoreactivity potentially trigger autoimmunity [7]. Regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, there is a theoretical risk of inducing autoimmunity and a number of reports of different autoimmune sequela [8]; however, most frequently used messenger ribonucleic acid (mRNA) vaccines have excluded patients with a history of autoimmune conditions from their clinical trials. The US Food and Drug Administration has raised the concern of possible precipitation of rheumatoid arthritis after SARS-CoV-2 vaccination [9]. Pfizer vaccine developers have included a list of rare complications, including myocarditis and skin reactions, in the information leaflet, but AA was not listed.
In addition to the morbidity burden of AA, it is distressing to affected patients and is associated with major psychosocial sequelae and reduced quality of life [10]. This report presents a patient with alopecia universalis recurrence precipitated by the SARS-CoV-2 vaccine.
Conclusions:
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Related Post on Alopecia World - COVID:
Comment
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Comment by Matt1 on September 11, 2022 at 9:15pm
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I ask anyone this question, find someone/ institution that has isolated covid 19, this is the first step in making a vaccine.
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Comment by dreamscometrue on September 11, 2022 at 8:12pm
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@Matt1 I recently was cleaning and organizing my parents home and came across vaccination cards for me and my siblings. It's truly undeliverable what has been allowed to be injected into our bodies as kids!! Dis-ease definitely comes from somewheres and something is the thing that triggered it.
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Comment by outforawalk on September 11, 2022 at 8:07pm
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I had the Covid Vaccines with no adverse reactions. I already had alopecia before them.
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Dreams come true you absolutely on the right path.
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Reading this somewhat makes me think that early childhood immunizations is what may have triggered my AA which culminated into AU from 23 yr old to the present 59 yrs old. I've always felt that way. No one else in my family has AA of any type, just me. But all my siblings do have some type of autoimmune disease; eczema and asthma. Im positive the correlation bwtn vaccines and autoimmune disorders is due to vaccines. Although now this article seems to take a stand as to informed consent, its too little too late as there are those who have been severely effected with adverse events, permanently disabled with no answers to how it was caused, and those who have died within days of vaccination. I dont think their defense will stand in a court of law for crimes against humanity and ill-informed consent. Unless a patient gets a complete list of potential side affects before immunization, its not full informed consent its considered an experiment.
2.5 yrs later, many unvaccinated people are still here and thriving. Those who did get the virus with no treatment, still here and thriving as those who are 2x vaccinated. I weigh the pros and cons to decide for myself if its worth the risk. But something is amiss for AA and vaccines, that Im sure of. AA didnt just come out of nowhere, unless it came from somewhere.
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