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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by Megn on
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I have friends with various arthritis and lots of money and they are reporting such amazing success for it and even Parkinson's. Wish the states would approve it. It would help nearly any autoimmune I would believe. One day.... :))
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Permalink Reply by Sabri on
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Ruxolitinib Is available in the uk at the cost of £3600 a month. Plus vat at 20%
http://www.ukmi.nhs.uk/applications/ndo/record_view_open.asp?newDru...
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That's over 50 k a year ! Let's hope other jak inhibitors get approved with a well higher safety profile!!
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My insurance covers Ruxolitinib
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Which company do you have? I am on Xeljanz and it's working, but curious to see in case I want to or need to switch for any reason. So far 8 weeks on Xeljanz and I look like a peach.
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Tufts - Ruxolitinib cleared up my nails / they were practically falling off. I didn't get any hair growth, but was only on it 4 months or so. I think it is a different Jsk inhibitor. I have three Xeljanz pills left - I might fall back on it.
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I got curious abt the stem cell treatments that cws mentioned, and this is absolutely amazing... There was a study done recently and the results are incredible. The article is kinda long and wordy, so if u want to see the results, skip to page 6 and 7. However, I read the whole thing since it was so interesting. Not only does stem cell treatment cute alopecia areata, it prevents it from relapsing. All you need is one treatment and ur hair will continue to grow even years after the treatment. There are virtually no side effects too! Here is a link to the study in case you guys are interested:
http://www.biomedcentral.com/content/pdf/s12916-015-0331-6.pdf
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Permalink Reply by 3ebdie on
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Ive read this article but i still think its not that impressive. I even think the picture they are showing of the alopecia patient is not genuine. Just look at it it doesnt look like alopecian bald spots. It looks like they shaved here so she can look like an alopecia patient before and after regrowth
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Looks interesting! If you you tube stem cell treatment for hair you will see a video on how they have successfully pulled this of in mice and was about to embark on their first human study! And the Dr in the video predicted it will be out in the next 5-10 years for human treatment of Alopecia however that was in 2008 ! Nearly 8 years ago! So I think this article is genuine and I just hope it does come out for treament very soon.
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I visited my dermatologist yesterday and she said was willing to let me try out xeljanz. However, she said wants me try something else first before trying xeljanz. She wants me to eat a gluten free diet for about two months to see if my condition gets any better. Apparently in some cases, gluten and some other foods are not tolerated by certain people's bodies and causes the their body to freak out and attack certain cells. I told her I would give it a try but I'm worried that it won't work. I've lost about 75% of the hair on my head already and the hair elsewhere on my body is starting to fall out too. I'm afraid that it might fall out completely by two months. I'm not entirely sure what to do, do you guys have any suggestions?
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Permalink Reply by DJ88 on
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Me personal, I would have said why not both? No guarantee that going gluten free will actually reverse anything. But, you've seen Xeljanz actually work for people. Plus, I've been to a few bad derms before I went AU and I don't 100% trust there word. I was once told Alopecia doesn't effect body hair, only the scalp and I stopped treating it until I loss my beard. It was too late and I went AU. So if I were you I'd go with the Xeljanz and it couldn't hurt to go gluten free as well. Im not a doctor, this is just what I'd do.
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