Alopecia World
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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by Rach1992 on
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But autoimmune alopecia can be triggered by stress, menopause, pregnancy or other hormonal factors. It's still alopecia, and if this treatment works on autoimmune alopecia, why wouldn't it work on autoimmune alopecia in some people and not others?
I mean, I don't plan to try an immune suppressant ever as I don't believe having hair back is worth having a higher risk of getting cancer, tuberculosis or any other disease but it's unfortunate that the treatment is not a sure fire hair-grower.
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Permalink Reply by LittleSadEyes on
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You’d be surprised to know that Jak inhibitors do in fact work for androgenetic alopecia. It’s like anything else, some people will respond and some others won’t.
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Permalink Reply by AlopeciaDestroyedMyLife on
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A huge number of people are getting growth and for the rest I believe it is just a matter of time.
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Hi Guys,
Just a quick little update .
I had another haircut in a proper style which I fill in with hair fibers. I am amazed at how different life is like this especially with the opposite sex. It's absolutely amazing to feel desirable and an equal to others. It feels very strange to have hair (almost like a dream) I often think I will just wake up one day and be back to where I was but no, It's real and it's happening.
Every day I look at the mirror no longer filled with dread , worry and despair but actually looking forward to seeing what new hairs are coming through. To not have to worry about losing anything any more is a immense load of my shoulders.
It's very odd but because I've had virtually nothing for so long I subconsciously still feel I have AU.
I will have some new pictures of my new haircut up shortly .
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Thanks Singh ,
How is your treatment going?
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Too early to say mate been just over 2 weeks. When did you start seeing growth mate? And does it come white at first or terminal ? Looking forward to ya new pic bro :)
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At the 7th month before I had anything significant.
On most people who have had alopecia for a long period of time it will normally start out as white , wispy vellus hairs that are hard to see and then progress onto full terminal hairs.
You'l get there eventually :)
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You did mention at one point you was on minoxidile and steroid shots ? Is that right mate ?
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Permalink Reply by Xeljanzmiracle on
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Beautifully said! I look forward to my new hair(s) everyday too. Today I saw my first blonde eyelash on the right side! I have about 5 dark one's on the left. ADML, has your left side been more dominant than the right?
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Hope it's just a matter of time to get my hair back,keeping my fingers crossed.Funny about the left side I did get some leg hairs more on my left,eye brows are fuller on the left side and the hair on my head that I still have more on the left!Believe I lost my hair due to a thyroid condition I got about 3 years before and a stressful event totally triggered it.Thats probably why it's not coming in now totally stressed because I'm one of the few people xeljanz isn't working on.And in my dreams I always have my beautiful hair!
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