Alopecia World
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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by HS on
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Hi Friends -
I have been on Xeljanz now since July 2, 2015. I have ALL my eyelashes, most of my body hair, and I had a full head of white fluff with some dark hairs growing in...and then in march, the hair on my head began to fall out. I still have white hair mostly on my head (although I look kind of like a troll doll with this long, diffuse white hair sticking straight up about 3 inches long.) At this point, it still has not all fallen out from my head... but it doesn't seem to be coming back either. Meanwhile, 6 weeks ago I got a set of injections in my eyebrows (where I had only soft white hair) and they grew in FAST. Dark, terminal hairs!
Has anyone else had an experience like this? Is there anyone who can give me some hope to hang onto? Thanks!
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Permalink Reply by Xeljanzmiracle on
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I'm sorry this is happening to you. Hopefully you are just going thru some type of "cycling" and new terminal growth will come in. There was someone on here who started losing hair on Xeljanz awhile ago, but I can't remember their name and we haven't heard from them in awhile to find out the latest with them.
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I wonder what happened to everyone that wrote all the time last year and then just disappeared.How are they doing?Are they still on xeljanz?Did all their hair grow in?Etc.etc.It would be nice to hear how everyone is doing.This site helps us learn from each other what is working what is not.We are the pioneers of this drug we need to stay in touch time to time.Keep everyone updated on their progress!
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Football Fan,
Would it be possible to communicate this concern at any Alopecia Areata conference?
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I have recently finished a 12 week trial using topical JAK inhibitors, if I am to respond to these drugs it will happen from now, I will post any reaction in the weeks coming up, if nothing I will consider oral Xel next year
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I have been using the xeljanz cream about 10 weeks now I plan on using it for 6 months.
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Football fans
I would like to say for that people when he or she regrowth their hairs no need to continue discussions, that's it, and I don't blame them gladness ...
what about you Mr Football fans !? any news
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It is a good source of information on the progress people are haveing with Xelljanz I can't seem to find anything updated on any other sites everything seems to be outdated and un informative. This site were dealing with other people that are in the same situation will continue to update my progress and hopefully it will keep others informed and possibly give them hope and strength good luck to all
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Another pharmaceutical company developing a JAK solution for AA, looks like this one is a modified oral ruxolitinib:
http://www.businesswire.com/news/home/20160504006458/en/Concert-Pha...
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