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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by cmdd20 on
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Think there are some other pharma companies (Aclaris Therapeutics for example) that have JAK drugs in their pipeline specifically for AA, but none yet approved.
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That is a great find cmdd20! But at just starting at phase 1 you think where still looking at about 5-10 years for this drug to come to market ? Also you think the price will cheaper ?
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No clue. I hope sooner given that there's been a lot of studies already done on ruxolitinib but could be wrong.
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Thanks cmdd20 and yeh I hope so too and you make a good point. Good find anyway mate and let's hope as this is exciting for all us alopecia sufferers.
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It's hard to put a timeline or cost on these biolagicals the Ruxubolatin is used for treating bone Marrow disorders and is very Expensive. The fact that they have identified the jak inhibitors are promising is great stuff. I had an appt with my reummatolagist today all my bloodwork is good I am currently on Xelljanz 5mgs twice a day and will be switching to Xelljanz xr which is a 11mg pill taken once a day. My doctor doesn't Beleive in perscribeing anything over the dose that Xelljanz recommends
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Yeh that is true James and thanks for the update ! Can I ask have you had any growth so far and how long have you been on xeljanz ?
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I have been on it for 7 weeks. Lots of growth on my face also inside my nose and ears scalp is starting to feel different but no hairs spike ing yet patience is important I Beleive I am on my way to recovery
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Permalink Reply by Jcortez05 on
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So I was always just using my copay card to cover the cost of xeljanz my copay card was running low so my dr said he would try through insurance and said they would prob deny it bc it was off label use but they approved it and I will be getting the new 1 pill a day xeljanz on Tuesday I was told through cvs without insurance it's $6,000 which seems very high considering the 2 pill a day was about $3500 .. I am going to speak to my dr about just taking the 2 pills a day form bc sometimes I only take 1 which is 5mg and I prefer that instead of 11mg
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Hi and your health very good? We must use it all the life?
i'm in my firrst 6 weeks and i'm afraid for the sides effect(at the moment noone ) ...
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My cholesterol has gone up its on the higher side my dr mentioned putting me on medicine to lower it
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