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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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Replies to This Discussion
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Permalink Reply by Nicolas on
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not only safer a lo ot safer approxly noone side effect cause it attack jack 1 and 2 no jack 3
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Why would not reccomend if in the trial whit alopecia the results are very good and it is safer???
i read this post and i can not understand if Dottor King is saying us the true about xelijanz side effects or not
Reply by Jen
Look at the data on the phase three studies. These are the first part of the safety profile graphs. I linked to above. All you have to look at is where the placebo is and where Xeljanz is to see the effect of the drug. And remember these were just short term studies. I would love to hear what Dr. King says to his patients about the safety profile. He seems like a very nice person. Maybe someone who has seen him personally can comment on his analysis of the risks.
In the meantime, here is a disturbing article about how stock analysts who invest in Pfizer see Xeljanz as unsafe: "The problem arose with some Wall Street analysts questioning Xeljanz's safety profile and wondering whether it was really a step up over Amgen's Enbrel and other plaque psoriasis medications already on pharmacy shelves. Though all approved medicines have possible side effects, Xeljanz's list of potential adverse effects is quite long. I suspect what really concerned Wall Street, and perhaps the FDA, was that Xeljanz can lead to an increased risk of developing skin cancer and lymphoma."
http://www.fool.com/investing/general/2015/12/22/pfizer-incs-bigges...
They can't get it approved for plaque psoriasis and they are looking for another market for it, they are happy to take Alopecia money in the meantime. They are selling a half billion dollars of it annually.
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I agree Jen I don't trust the FDA or most pharmaceutical companies as most of them are in it for profit only ! But unfortunately this is how the world revolves over money and propaganda! However this truth is we can say cigarettes and alcohol have killed more people than xeljanz and any other jak inhabitors put together and there is no denying that. Yet the government has not banned it or bought out much study on why etc because it makes money.
I think if people stop buying hair products like laser cap etc the cure or treatment would come out quicker bcz they would want to make up there money in the alopecia market.
And alopecia although it may seem it doesn't affect the health of a person should not be ignored as it is an immune disease and can lead to other diseases If left untreated I.e rumotoid arthritis.
Some people think it's just hair loss but the reality is there something wrong with our Immune system that cannot be ignored and does need to be cured and treated.
Sorry if this has been a long read people am
Just making a valid abs realistic point whichever side you want to look at it.
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You nailed it
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Singh,
This is so valid. I do believe people with alopecia have a strong non-profit that directs money in the right way, not just toward treatments, but to greater genetic understanding. Researchers have only scratched the surface of understanding alopecia and related conditions. Keep your non-profit NAAF strong and get involved.
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Yeh Beth and compared to a few years ago there was no hope now they have discovered the pathways that attack the hair follicle we have abit of hope and I feel in the next coming years they will find out what courses alopecia and to hopefully they will prevent and cure it. Put it this way whoever comes out with the cure is a trillionare ! So I can see why scientists want to find the cure.
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There is a reason why it is still not approved in the EU... My docter said that it won't be here before 2018 (if it'll ever be approved).
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Dolly! I think because new drugs and for trial now , but I think most people get respond, and you have to be patient , and you can get Xeljanz from Turky it's very cheap .
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No dolly I think is going to get approved this year in the uk and EU as its already been pre-approved and filled for pre registration so even mybe next year.
However it will not be approved for alopecia but only RA.
http://www.ukmi.nhs.uk/applications/ndo/record_view_open.asp?newDru...
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