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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by kevin on
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Hello so xeljanz would not be effective this is scary. So xeljanz is like the steroid there is relapse despite that the are always in treatment?
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some treatmente last over 15 years for some patients... some might never have to switch from a biologic to another it's you and your luck. xeljanz is effective because even if you do not respond after 10 years well in 10 years there might be another biologic to switch for. for example rheumatoid arthritis has been treated with biologics for more than 15 years to my knowledge...
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Thanks for the info. I got AA when I started on Enbrel ( no prior history or heredity) but it was terrific for the RA. Stayed on it until it stopped after 2 years, Humira didn't work for RA,Actemra was ok but went to Au on this one. Then tried Xeljanz. Guess I will have to either go back to Actemra and accept that nothing can help AU yet.
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all the best for your RA and AU. theses diseases are so difficult to treat... but you never know, your AU could stop with your next treatment.
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Are you seeing any results with xeljanz?
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Hello alopecia destroy my life always has her hair people who are in the long term can give new thanks because people do not feel this concerned but from the illness come back people cry
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Hello alopecia destroy my life always has her hair people who are in the long term can give new thanks because people do not feel this concerned but from the illness come back people cry
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Hey guys,
I have been on xeljanz for approximately one year with full regrowth. However, as of late I have notified that my eyelashes have been shedding more then usual. I am hoping this is just a normal shed cycle, and nothing else.
Does anyone have any thoughts about this? Thanks.
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Are you stll taking xeljanz?
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Yes, same dose. Nothing has changed.
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Hey xeljanz girl, have you tried upping your dose ? As it's possible your body has come immune to xeljanz meaning if you maybe up your dose it could confuse your body/T-cells to be active towards xeljanz.
Kind regard
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Thanks for the response! I am going to give it another month or two to see what happens. My hair on my head seems to be growing and staying put - so I am hoping it is just a regular cycle for my lashes. I will keep everyone posted.
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