Alopecia World
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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by Football fan on
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Let's keep our fingers crossed something gets approved soon!You made my day!!
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that's very good news.
don't want to sound like the party pooper but phase 1 takes longer time before they reach and finish phase 4...
but the treatments are there at least. it's just a matter of time. thanks to all the scientist working on this.
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How long do you think the whole process takes?
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well that is a tough question... but based on my experience on Market Access in different pharmaceutical companies that I worked for, I would say at least 2,5 years. and that's optimistic.
look, from scratch meaning step 1 in laboratory a new drug takes around 15 years to reach the market.
the preclinical takes a lot of times, at least 3 years. this is when they test it on animals.
phase 1 takes in general 6 months to 1 year. would be good to see how much time it took in this case. phase 1 is done with healthy volunteers.
phase 2. this is when they test it with alopecians. another group also will receive placebo or another standard treatment... this phase takes 6 months to 2 years. this phase is usually where most new drug do not succeed.
phase 3. it's like phase 2 but done with much more patients so we have more data. hospitals are generally involved... adverse events are looked into very deeply. this step takes usually 2 years. sometimes even 3.
I assume you are in the USA. after phase 3 the company request the approval to the FDA.
phase 4 is post marketing. they will check the efficacy and secondary effects on the public.
The pros: in 2015, FDA listed Alopecia one of the 8 disease they will really focus on in order to get a treatment. that's good news and maybe a reason the whole thing will go faster. this is not a totally NEW DRUG. it is really similar to ruxolitinib, just a modified version of Jak 1 and Jak2. this should accelerate the whole process by a lot.
the downside: The idiot your country elected recently announced MAJOR cuts in clinical trials and research to support the increase budget of military. it's 2017 I can't believe tanks and weapons of mass destruction are more important than Health.
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Permalink Reply by Alo-mom on
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Thank you for your explanation of the process. NAAF has worked very hard to bring this condition to the attention of the FDA. I have written my thoughts on AW regarding the need for those with Alopecia or a love one that has it to call their representatives and tell them NO NO NO to cuts to medical research and to FULLY FUND THE NIH who doles out the federal monies for research. WE will do ourselves a huge dis- service if we sit there and do nothing regarding this very important issue. We really have sold ourselves short with someone in DC that really does not care about the health and welfare of our country. NO POLITICS BUT LETS MAKE THE CALLS or write an email to these representatives. Every day I make a call or write a note. They do not have to be long or complicated. Just call and say who you are and why you cannot accept cuts to medical research and to fully fund the National Institute of Health.
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Calling them won't help unfortunately. Govt doesn't care about people's interests. Look at any vote in house or congress they're basically always along party lines, its gross and really is taxation without representation.
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is vitiligo one of the 8 diseases
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don't know but I know some companies have vitiligo treatment in their pipeline. aclaris is one of them I think.
good luck buddy
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Thank you so much for taking time to reply back with the info. Do you know what phase we are at now for alopecia?
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xeljanz was approved in Europe for rheumatism, I hope that we can buy in any European country without going to Turkey.
Pfizer's Xeljanz Authorized for Marketing in the European Union
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