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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by blondfrog on
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http://www.hairlosscure2020.com/category/angela-christiano/
some new exciting news they found that hair grows much faster in mice when applying it with a cream within 10 days
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This is exciting news. If these drugs work on MPB then the big pharm companies should take notice and get it to market much faster which will help all of us.
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Permalink Reply by 3ebdie on
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From the article about the topical jak:
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Pharmacological inhibitors of JAK-STAT and other drugs used in this study
Ruxolitinib was purchased from ChemieTek (catalog no. CT-INCB). Tofacitinib was purchased from AbMole BioScience (catalog no. 477600-75-2). Hedgehog agonist (SAG) was purchased from EMD Millipore (catalog no. 566660). JAK-STAT inhibitors were dissolved in DMSO and used at 2 to 3% for in vivo experiments, as indicated, and 400 nM for in vitro experiments. SAG was used at 120 μM, as described by Paladini et al. (2).
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Anyone here with a chemistry background? How much mg of ruxolitinib (molecular weight of 306.37 g/mol) do we need to make a cream of let's say 250ml with a concentration of 2/3%?
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Im no chemist but:
Predicted Density of Ruxolitinib(which I found online) = 1.4 g/mL
.02 x 250mL = 5.0 mL of Ruxolitinib
.03 x 250mL = 7.5 mL of Ruxolitinib
Mass = Volume x Density
Mass(for 2%) = 5.0mL x 1.4g/mL = 7.0 grams or 7000 miligrams
Mass(for 3%) = 7.5mL x 1.4g/mL = 10.5 grams or 10500 miligrams
So to produce 250mL of a 2/3% Ruxolitinib solution, you would need 7000/10500 miligrams of Ruxolitinib.
Once again, I am no chemist, I took AP Chemistry as a sophmore in highschool last year. If there are any real chemists here, please verify. Also, much more information is needed in order to truly find the amount of compounds they used in their cream. They may have in fact mixed tofacitibib and ruxolitinib together into one cream which would alter the results. And it is not stated what the solvent of the cream is either. There are a lot of unknown variables. My calculations are most likely estimates if not wrong. The calculations seem reasonable, however, because 250mL is a quater of a Liter of solution, which would most likely contain a large amount of Ruxolitinib. I did these calculations for fun, please dont take them too seriosuly lol, but it should give you a general idea of about how much Ruxoltinib would be in a cream.
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My dermatologist told me a few months ago he had a patient who had xeljanz made into a cream from a compound pharmacy.Th e good news was it worked and he grew hair the bad news was it cost more to have it made into a cream than to just take the pills.Also what if you don't have eyelashes the cream applied to your scalp probably won't grow them back in?
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Thats true, if you are universalis, the pill is probably the best and only way to go. But the cream may help speed up the process or maintain your hair if you switch to a lower dosage. The cream has a much faster response rate than the oral pill, so it will be cool to see how doctors will use the cream, possibly alongside the oral treatment.
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I think when I finally get it I will crush 2 pills in to powder and mix it into some face cream. Then apply to eyebrows. I will see what will happen in 10 day of doing it.
The report says the cream works in 10 days.
Worth a try to boost the eyebrows.
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Permalink Reply by sadele on
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I am at a loss... About to finish month 4 and haven't seen anything worth reporting yet :(. 2 months ago approximatly 50 tiny little white hairs sprouted but they haven't done anything since. Nothing on brows or lashes either. I'm on 4 pills a day, you would think something would start to respond. I'm so frustrated.. And incredibly sad.
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