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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by Return_life on
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always optimistic. how is ur regrowth
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Hi all, thank you for interesting discussion.I currently cant afford to buy xeljanz topical but would like to have it to put on my eyebrows. I lost my hair and eyebrows in 4 mnth period. Is anyone willing to sell xeljanz topical they arent using? Thank you.
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I dont think anyone here has the topical xeljanz
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I had been on Xeljanz for RA and AU for 3 months with great results. However, I got a UTI and as I'm allergic to several antibiotics, it took 2 months to settle. Being off Xeljanz for that time made my hair fall out. I have been on it again for last 3 months with no hair growing back at all and it has stopped working for the RA. Has similar happened to anyone else?
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this is something common with biologics.
this is what physicians call a naive patients, first time user. patients often switch from a biologic treatment to another on a long term. even if you don't stop after a few years it could stop working just like that, I know it sucks. for example psoriasis patients could switch from Humira to enbrel and stelara. unfortunately doctors do not try lots of other biologics for AU so ask your rheumatologist what he can do for your RA. there is a person on this site with crohn disease and AU. she was given Humira to treat Crohn but guess what, it treated also her AU. this means Humira could also treat AU for a few other people. I have been working many years in the immunology department of various big pharmaceutical companies. like 99% of other autoimmune disease, the treatments are immunosuppressive like biologics. but because the market share of Alopecia is a very small one they were not interested to get this indication (alopecia). I know it sounds sad but knowing that xeljanz treated alopecia wasn't that surprising... we didn't know which drug had a potential but surely the solution was there. especially with all the biologics available today on the market... hope it helps!
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Permalink Reply by Rascalx2 on
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Do you know who or how I can get in touch w person who went on humira w crohns? I have ulcerative colitis and AU. Xeljanz has not been shown to be very effective for me... maybe humira would be more effective
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if u are in Canada I can help u get Humira for free... where u from.
UC is very close to crohn disease so yes try this.
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I have ulcerative colitis, My GI MD would wrkte me script for it, I have peach fuzz w xeljanz, gonna try for few more months but am going to research humira. I did read that immunosuppressant such as humira can cause alopecia. I was on 6mp ( mercaptopurine ) for few years for colitis, worked well. After I went off it .. few months later went AU. Sometimes wonder if 6mp aas keepi h alopecia from happeneing.
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My son has crohns and is on Humira. He does not have Alopecia but my older son does
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Aimee she is on this site. she might give you more details
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