Xeljanz (Tofacitinib Citrate): My experience on the trial

I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.

I thought it would be nice for everyone if I documented my progress on here. 

Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.

The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results. 

I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.

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AW:  Other discussions on Xeljanz / Tofacitinib

https://alopeciaworld.com/main/search/search?q=Tofacitinib

 

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Permalink Reply by Alop88 on March 10, 2017 at 11:36am

Will this be safer (regarding side effects) than Ruxolitinib and Xeljanz?

Permalink Reply by Patchesforlife on March 10, 2017 at 5:06pm
Thank you!! Is this supposed to be much safer than xeljanz?
Permalink Reply by Villa fan on March 10, 2017 at 11:18am

Has anyone managed to claim the tax back on Xeljanz brought in Turkey?

Permalink Reply by James 2me on March 10, 2017 at 2:07pm
This is a proven fact I had about 60 % scalp full eyebrows full lashes along with body hair after 8 months. Started feeling sick and not myself so I stopped Xelljanjz tried going the Hollistic Route with all the restricted foods. Hair was completely gone in two months. I busted started Xelljanz again along with a new type of injectable Methotrexate used once a week. Starting to see slight progression.
Permalink Reply by singh on March 11, 2017 at 4:40am
Hi James just wondering did you get beard growth too?
Permalink Reply by Siella scott on March 11, 2017 at 5:19am

Does anyone wonder if these posts regarding biologics might be a "bait". Spend a lot of time researching things you read about. Not everything is going to work. If you study people who have been around this site for long times, you might be able to save a lot of money and repeated grief by losing more than our hair. Trust me, losing kidney function, liver crapping out and being in horrific pain makes a person think more than once about putting more poison in my body than whatever caused AA, AU, or AT in the first place. Some things just don't add up! My opinion only.

Permalink Reply by dreamscometrue on March 11, 2017 at 5:49am

I think you have a point, but that's also a very pessimistic POV.  Without research, trying to figure it out, trial and error, no one knows what will or will not work.  But even a pessimist can benefit if something good comes out of it, like a cure or treatment, so, why would anyone spend more time posting about how bad they feel having a disorder when we can spend time forging forward, offering positive POV and perhaps sharing positive results when we have them? Imo

Permalink Reply by dreamscometrue on March 12, 2017 at 11:14pm

I just found this very interesting article and product.  Please anyone interested take a look!

http://www.regenerativenutrition.com/shop-product.asp?prod=140

Permalink Reply by Starshine on March 13, 2017 at 3:30am

I took this faithfully for over a year with no results.

Permalink Reply by AlopeciaDestroyedMyLife on March 13, 2017 at 5:45am

Hi Starshine, how many mg were you taking a day?

After speaking with Dr King most people respond but there has been a few who have not unfortunately. Not within a year time frame at any rate. 

My next step at that stage would be a combination treatment of minoxidil, cortisone injections and xeljanz. 

Permalink Reply by Starshine on March 13, 2017 at 10:51am
Hi ADML, good to hear from you! Actually I was responding to the person who had posted about Kalawalla, which I had tried before Xeljanz with no results. I have bern on Xeljanz for two years now with full regrowth and no relapses. I was wondering though about the possibility of decreasing the dose or finding a maintenance dose now that all of my hair is back. How are you doing? Have you had any relapses, as a few people on here have had some set backs and others do not seem to be responding at all, although the majority are. Please post some pics if you can and give everyone an update. A lot of people have asked about you. Are you still seeing Dr. King?
Permalink Reply by Football fan on March 13, 2017 at 12:44pm
Hi star shine what dosage of xeljanz are you taking and did you ever get pigment in your hair.That is an excellent question has anyone been able to reduce their dosages with success?

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