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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by Jim In Cali on
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http://stemcellrevolution.com/stem-cell-research-studies/autoimmune...
Stem Cell Revolution, I spoke to Dr Lander, who was one of the co founders. They also have 2-3 other procedures for Alopecia. Plus you get a free liposuction out of the deal because that's where they harvest the stem cells from. Dr Lander said autoimmune diseases respond very well to their protocols. Until you see peer reviewed research data you take statements of how effective it is with a grain of salt. If I had $8,900 to throw away I would totally try it. If I have a good year I'm going to try it. One positive is their are 3 other companies developing the same procedures.
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Who here has reported that they sustained their hair regrowth when they stopped medicating with Xeljanz?
or anyone sustaining growth for 6+ months on a maintenance dose?
Is Dr. King's original patient with plaque psoriasis and AU still here to report back on his current regimen?
Thanks everyone.
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I would love to know if you find out! Last I heard, Dr. King's original patient, Kyle, was still on Xeljanz and still has his hair. I just stopped after three months and I am scared. Someone reported that the mice in the trial lost their hair after stopping -but I can't seem to find that data.
-Tara
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http://www.bloomberg.com/apps/news?pid=newsarchive&sid=a6OdEa5V...
I always tout the amazing results of this study but it seems to be ignored by the major players in the hair loss community.
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http://www.biomedcentral.com/content...015-0331-6.pdf
Stem Cell Educator Therapy. Hopefully more things like this will be researched...we ultimately need a long-term "cure".
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Permalink Reply by DJ88 on
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Xenjanz cant be used longterm? Isn't Kyle Rhodes still on it? I just assumed someone could use it like Rogaine.
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Yes, it could be used long-term as long as your body allows for it (as far as we know...these JAKs are a new biologic with no real long-term studies). However, the safety profile for stem cell therapy is much, much better. It could also potentially be cheaper if the results last years.
My point is that the new research needs to be pointed towards re-educating our immune system to give our hair follicles the immune privilege they once had. Until we can "turn-off" the production of the problematic protein in the dermal sheath of our hair, we will have to work on "educating" our T-cells/ immune system.
Once the days of quantum computing arrive...the doors might be blown open for medical research. Those days are coming.
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Kyle Rhodes took Xenjanx for rhumitoid arthritis, was only by accident it grew hair. As of right now it's only available as a pill. Trails are looking at making it a topical solution, which hopefully eliminate the negative aspects. My friend has rhumitoid arthritis, their are some days he can't walk, or uses a cane, which is rough for a guy who runs marathons. Kyle, like my friend take it just to function day to day.
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Permalink Reply by Xeljanzmiracle on
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Hate to burst your bubble but no, Kyle DID NOT take Xeljanz for RA. He had psoriasis and AU, two other autoimmune diseases. Dr. King, a dermatologist, DELIBERATELY tried Xeljanz on Kyle hoping it would help with his psoriasis and hair regrowth and it did. It was not an accident.
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The latest article which cws posted is a study with astonishing results. I'm a bit surprised as to why these latest findings haven't made the same kind of splash that xeljanz did. Last year we heard of one individual (Kyle Rhodes) who responded well to xeljanz and almost every news outlet out there picked up the story and ran with it.
These recent findings show how 8 out of 9 individuals regrew their hair, and maintained it (now for almost 2 years) after being treated with stem cell therapy, yet it did not seem to make a blip on the media radar.
From what I can gather these findings are not being published by quacks. Am I being to optimistic here? Should these findings not be treated with the same kind of gravity that last year's findings were because CNN, BBC and other media outlets didn't report on it? Perhaps I am missing something here, if so, can someone please clarify.
Much thanks!
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Permalink Reply by tall blonde 1 on
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I am thrilled to hear this! I have been eagerly wanting to try Xeljanz. I have arthritis as well, so I hope I can score some!
Fingers crossed for you!
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