Xeljanz (Tofacitinib Citrate): My experience on the trial

I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.

I thought it would be nice for everyone if I documented my progress on here. 

Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.

The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results. 

I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.

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AW:  Other discussions on Xeljanz / Tofacitinib

https://alopeciaworld.com/main/search/search?q=Tofacitinib

 

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Replies to This Discussion

Permalink Reply by AlopeciaDestroyedMyLife on July 27, 2015 at 4:39pm

That's how it all starts Jckah ! Can clearly see vellus hair there .  

Permalink Reply by AU1989 on July 28, 2015 at 10:01am

Hi all,

I'm 4 weeks on prednisone pulse and xeljanz and seeing alot of vellus hairs on the top of my head- pretty much all over but I'm still nervous because its been 3 years since I had any hair and have had AA/AT/AU for over 20 years.  I'm trying to be patient but it's not working :)

Permalink Reply by Megn on July 27, 2015 at 7:22pm

Hooray!  I am so excited to see this!

Permalink Reply by cws on July 27, 2015 at 3:53pm

http://www.medica-tradefair.com/cipp/md_medica/custom/pub/content,o...

Looks like some more discoveries...I think the research in autoimmune in the broad sense has the most potential for a viable long-term treatment/ cure.

Permalink Reply by AlopeciaDestroyedMyLife on July 27, 2015 at 4:37pm

Nice find CWS 

Permalink Reply by kevin on July 27, 2015 at 5:22pm
Permalink Reply by Mike on July 27, 2015 at 10:34pm

Has Dr. King or any of the other doctors doing the trial studies said anything about other medicines someone might be on while taking Xeljanz? ie...Blood pressure/ cholesterol ..thank you.

Permalink Reply by AU1989 on July 28, 2015 at 8:30am

I take simvastatin and there are no issues per Dr King

Permalink Reply by Mike on July 28, 2015 at 9:22pm

Thank you AU1989. Can anyone who is currently on Xeljanz tell me what kind of blood work should be done exactly by my doctor before starting on it please?

Permalink Reply by lusha22 on July 28, 2015 at 10:13pm
Hi mike! I had a cmp, cbc, lipid profile and a TB test done prior to starting.
Permalink Reply by Mike on July 28, 2015 at 11:08pm
Thank you for the information:)
Permalink Reply by vjensen14 on July 28, 2015 at 11:19pm

Hi! Im Victoria I have AA that was progressing rapidly into totalis. I have been on Xeljanz for 10 weeks now and my hair has finally stopped falling out and is growing back! I am very excited!! These are pictures from 5 weeks when it first started to grow in and then now at 10 weeks. Hope this gives everyone some hope!!!

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