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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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Replies to This Discussion
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Permalink Reply by Jckah on
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I developed a little acne on my face but really bad on my chest, basically looks like blisters.
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Permalink Reply by Megn on
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Ok, I am an esthetician WITH AU......FedEx is delivering my Xeljanz today.
As a woman with AU and in skin care (for 15 years) I am going to take a really close look at how to treat any breakouts. This side effect (while minor) cannot be a new norm for me.
I am hoping not to get acne, but believe me, if I do......I will find a safe solution other than more oral meds.
Blister-like acne? That sounds painful! I wonder what part of the medication mechanism is causing people to get acne. (men and women?)
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Permalink Reply by katiegirl on
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My acne is pretty much localized just to the face. Forehead and around the sides of my face.
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Mainly face, but I did have a break out on my
Upper back for a few days. (Now gone)
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Ok ladies!
Is there new vellus hair in any of the acne areas?
Does anyone have a Clarisonic Brush that they are using/
How about topicals? Acne OTC products?
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I've been on it for about 6 months and I did get a little acne but not much... basically this medicine limits your body's ability to fight infection (it alters the immune system) and acne is essentially little infections so this makes sense.
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I see my doctor tomorrow morning to have blood work done and am starting Xeljanz tomorrow. I haven't had any hair on my head or body since I was 12 in 7th grade and I'm now 47. I've lived with this for over 35 years. I'm nervous and optimistic. Here we go...
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I understand Mike. Im mid 40s too. I've had no hair since 2012 but alopecia in various forms since 1989. Good luck!
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