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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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AW: Other discussions on Xeljanz / Tofacitinib
https://alopeciaworld.com/main/search/search?q=Tofacitinib
Replies to This Discussion
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Permalink Reply by Merry on
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Lattisse only works if you already have lashes. It keeps them from cycling out and therefore they grow longer, but it doesn't make lashes grow in if you have none. I have used it in the past, but it is $150 per month, not covered by insurance, and I can't tell it has worked for me. My lashes are so light in color that I prefer to use that money to get lash extensions that really make a difference.
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Thank, I would not have know that unless you chimed in. This a helpful site.
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I used lattisse before I got Alopecia my eyelashes and eyebrows thinned a little but I kept enough to look normal.My doctor sells it for $125.and it lasts about 2 months but I found it in Mexico for $40.going back there this weekend to pick up more.
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Permalink Reply by ChrisPowers on
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Incidentally, Latisse is known to cause changes in one's eye color, specifically darkening it. For this reason, I stayed away from the stuff. I'd like to have hair, but not at the expense of the rest of my features.
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My daughter has been on Xeljanz since December to treat her arthritis. She also has alopecia. Since starting Xeljanz her joints are so much better! And as an added benefit, her hair is growing again. :) She is so excited to have eyelashes again!
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Has anyone heard any news about barcitinib it was suppose to come out last year it is a jak 1 and jak 2.Was hoping it would give those of us not responding to xeljanz another option.
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Hi Football fan it has been granted a license in the uk and Europe. But not seen any studies on it for alopecia. It is approved for arthritis. I think it has been denied by the FDA in the U.S but is available in the UK.
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Permalink Reply by Suzie on
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So glad to hear she is getting relief for both autoimmune diseases. I hope she continues to have success! I have RA and AA. RA since age 26 and AA only twice (once as a teenager, then all grew back on it's own with no meds or anything and then 3 years ago (but this time I lost a lot more hair! and since I had RA I decided to change my meds from Orencia to the Xeljanz and I, too, have had great success with the RA and AA! My best to your daughter!
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Has anyone tried EGCG. I green tea extract that is supposed to help with inflammation. It has something to do with interluken 1. I may have really spelled that wrong.
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I have been taking a relatively potent green tea extract with high EGCG content on and off (mostly on) for years now. It has done nothing in terms of hair growth. Granted, I have a pretty recalcitrant case of AU, but I wouldn't put too much hope in it, personally.
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