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Xeljanz (Tofacitinib Citrate): My experience on the trial
I have received a lot of interest from others on here in my involvement with the Xeljanz trials at Yale.
I thought it would be nice for everyone if I documented my progress on here.
Xeljanz is a Jak3 inhibitor and is believed to work with alopecia by turning off the distress signal relayed by the hair follicle to the attacking immune system which is the cause of the hairs falling out. Xeljanz comes in a strength of 5mg per pill and a full box contains 60 tablets. The recommended dosage for arthritis is 1 tablet in the morning and another in the evening each day.
The trial is set in a series of stages and there are requirements before participating. These include monthly visits and blood tests every 2 weeks. Dr Brett King is absolutely fantastic and is an inspiration to me. His positivity and enthusiasm gives me the much needed hope I have craved for over a decade. I have been put on a low dose to start with which is 1 tablet every other day. My dosage has now been increased to 1 tablet every day and next month it could be increased to 2 tablets per day depending on the results.
I have completed my first month and have already noticed my alopecia has stabilised . I have not lost any existing hairs. In addition to this I have seen little hairs growing in my chest area as well as eyebrows. Fingers crossed! To date, I have experienced no side effects.
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Replies to This Discussion
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Permalink Reply by Suzie on
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Sasha, this disease is so unpredictable to say the least....as a teenager I developed this (AA) (and this was 30 years ago and no one knew what I had). It ALL grew back on it's own with no medicine, no injections no NOTHING. Then I developed RA after the 2nd child when I was 26. Throughout the life I had a small patch here and there but was never concerned because it was hidden and it grew back. Fast forward at the age of 48 and all of a sudden lots and lots of patches, excessive thinning and all. I asked rheumatologist to be put on Xeljanz after much research and it has helped my RA and the AA. But after all of my patches have filled in I now have developed Androgenic Alopecia......unbelievable! I'm not sure if the Xeljanz will help this or not.....Hang in there. Hopefully your body will adjust and will stabilize and keep working for you.
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Permalink Reply by thehairartist on
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Has anyone had any successful diet shedding xeljanz weight gain? I've gained 10-15lbs and I'm struggling losing any weight. I've lost 110lbs doing keto and my body seems like it doesn't want to co-operate. I'm wondering if it's xeljanz or something I need to change.
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Hi Newjack , how long you are using xeljanz? For me it’s been 4 months and not really gained and I eat almost everything,
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U started 3 weeks before me then, Have you had any regrowing hair?
Mine is fine blonde hair and increased to 15 mg recently and coming some dark thin hair but I feel slow, maybe don’t have patient;)
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Newjack, I first developed weight gain, but have since joined a gym and not I'm having the opposite problem with losing too much. I've also been diagnosed with Hashimotos since that time and going through Menopause, so I'm not sure what is causing what. Good luck!
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Has anyone heard of any new treatments for Alopecia. I read something about a jak inhibitor cream that helped a 17 year old girl regain growth. Dr King did the treatment! Anyone know of new products and when possible opportunity may be.
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Know the feeelibg! I’ve gained too! But I was too skinny before (hashimotos - hyper) but I’m noticing that like the acne the weight gain is going down with time. It’s almost like the body blows out at first, adjusts and then goes back to normal. My acne at first was bad - now, I’m a bit more diligent with face washing etc but it’s mosty just gotten better- a spot here or there. If it makes you feeel better you still look slim in your progress pics:). Also I had a friend on serious Keri (I did lazy girl keto but I like my fruit and veggies too much)- she lost heaps but then it stopped working and she gainned... she changed it up to a more moderate carb approach and lost again - body just needed a change I guess!
Ps check your thyroid too if you haven’t - a lot of us seem to have thyroid issues - hashimotos can make you gain or lose, and make it difficult to lose weight. Read somewhere keto can be a bit tough on the thyroid though other places say the opposite. Tough to know which way to go these days re diet!
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